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NPPA — TNF

Text-mined interactions from Literome

Kiemer et al., J Immunol 2000 : To investigate the underlying mechanism of ANP mediated TNF-alpha inhibition, Northern blot was performed ... ANP significantly attenuated production of TNF-alpha and IL-1beta without affecting production of IL-10 and IL-1ra
Kiemer et al., J Hepatol 2000 (Ischemia...) : In contrast, a profound expression of transcripts coding for TNF-alpha was detected in the course of reperfusion and ANP markedly reduced TNF-alpha mRNA expression
Tsukagoshi et al., Regul Pept 2001 : Human ANP ( 99-126 ) and a specific p38 MAP kinase inhibitor SB203580 inhibited the IFN-gamma induced TNF-alpha production in a dose dependent manner without affecting NO production
Kiemer et al., Shock 2002 : ANP significantly reduced lipopolysaccharide (LPS) induced tumor necrosis factor alpha (TNFalpha) secretion, paralleled by an increased cell associated TNFalpha ... ANP reduced TNFalpha release possibly by influencing post-translational processing of TNFalpha in LPS activated KCs
Nakayama et al., J Pharmacol Exp Ther 2007 (Reperfusion Injury...) : ANP inhibited I/R induced increases in spinal cord tissue levels of tumor necrosis factor and myeloperoxidase
Borán et al., Glia 2008 : However, ANP does not induce NO synthase Type 2 (NOS-2) or tumor necrosis factor-alpha expression and is able to decrease lipopolysaccharide (LPS) elicited induction of these inflammatory genes
Xing et al., Microvasc Res 2010 (Inflammation) : Consistent with protective effects on EC permeability and monolayer integrity, ANP dramatically attenuated activation of inflammatory signaling by LPS and TNFalpha in pulmonary EC ... These results strongly suggest inhibitory effects of ANP on the LPS and TNFalpha induced inflammatory signaling as additional mechanism of EC barrier preservation in the models of acute lung injury and sepsis