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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to ATM

ATM — E2F1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: E2F1 → ATM (increases, E2F1 Activity)
    Evidence: In response to genotoxic stress (i.e. DNA-damaging agents), the E2F1 protein is stabilized through distinct mechanisms including: (i) direct phosphorylation by ataxia-telangiectasia- mutated (ATM) kinase, ATM- and RAD3-related (ATR) kinase and checkpoint 2 (CHK2) kinase and (ii) acetylation through p300/CREB-binding-proteinassociated factor (P/CAF)
  • OpenBEL Selventa BEL large corpus: E2F1 → ATM (directlyIncreases, E2F1 Activity) Lin et al., Genes Dev 2001*
    Evidence: PhosphoElm data from PMID 15212693

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *