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IL2 — PRL

Text-mined interactions from Literome

Kanda et al., J Clin Endocrinol Metab 1999 : Interleukin-2 inhibits the synthesis and release of prolactin from human decidual cells ... As interleukin-2 (IL-2) stimulates the synthesis and release of pituitary PRL, and decidual stromal cells have receptors for IL-2, we examined whether IL-2 also regulates the release of decidual PRL ... The inhibitory effect of IL-2 on PRL release was secondary to inhibition of PRL synthesis ... These findings strongly suggest that IL-2 inhibits the synthesis and release of decidual PRL and provide further support for a critical role of cytokines in the regulation of decidual PRL gene expression
Belkowski et al., J Neuroimmunol 1999 : The immunosuppressant rapamycin markedly inhibited IL2 induced proliferation and prolactin translocation to the nucleus
Hinterberger-Fischer et al., Acta Med Austriaca Suppl 2000 (Breast Neoplasms...) : PRL is necessary for IL-2 mediated activation and proliferation of T-cells and NK-cells and for LAK-cell generation, where optimal effects are found when low IL-2 levels are combined with PRL levels just above the upper normal range
Matalka et al., Cytokine 2003 : Prolactin enhances production of interferon-gamma, interleukin-12 , and interleukin-10, but not of tumor necrosis factor-alpha, in a stimulus-specific manner
Sun et al., Cell Res 2004 : PRL increased expressions of IL-2Ralpha on membrane and of IL-2 mRNA in cells, indicating that PRL up-regulated NK cell function by improving positive feedback between IL-2 and IL-2R
Gerlo et al., J Neuroimmunol 2005 : We established that both IL-2 and IL-4 reduced PRL mRNA levels in T lymphocytes to 25 and 28 % of control values, respectively
Lee et al., Cancer Res 2005 (MAP Kinase Signaling System) : To delineate the signaling mechanism from 16-kDa PRL, we examined the effect of 16-kDa PRL on interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB)
Bukulmez et al., BioDrugs 1997 : In the central nervous system, interleukin-1 (IL-1) decreases gonadotropin releasing hormone and luteinising hormone levels and increases prolactin levels
Karanth et al., Proc Natl Acad Sci U S A 1991 : IL-2 stimulated the basal release of PRL at 1 or 2 hr but suppressed the subsequent depolarization induced PRL release, perhaps because the readily releasable pool of PRL was exhausted
Viselli et al., Endocrinology 1991 : PRL can induce interleukin-2 (IL-2) receptor expression in splenocytes from ovariectomized ( OVX ) female rats ... In this further study of the effects of PRL on lymphocytes in vitro we found that PRL induced IL-2 receptor expression, IL-2 production, and proliferation of splenocytes and thymocytes from OVX rats
Jara et al., Semin Arthritis Rheum 1991 (Arthritis, Experimental...) : Prolactin is comitogenic with concanavalin A and induces interleukin 2 receptors on the surface of lymphocytes
Clevenger et al., Proc Natl Acad Sci U S A 1990 : Interleukin 2 stimulation induced the translocation of prolactin into the nucleus and prolactin receptor to the nuclear periphery
Mukherjee et al., Endocrinology 1990 : Prolactin induction of interleukin-2 receptors on rat splenic lymphocytes ... We studied the in vitro effects of PRL on splenocytes from ovariectomized ( OVX ) rats and discovered that PRL induced the formation of interleukin-2 (IL-2) cell surface receptors ... However, PRL did not induce IL-2 secretion
Gushchin et al., J Neuroimmunol 1995 : These findings suggest that the complete mitogenic effect of PRL on Nb2 cells requires stimulation of IL-2 production
Mukherjee et al., Endocr Res 1994 (Mammary Neoplasms, Experimental) : Splenocytes from the treated animals, 2-6 weeks post-injection, expressed fewer IL-2R in response to standard PRL
Gutierez et al., Rev Rhum Ed Fr 1994 (Rheumatic Diseases) : Prolactin is co-mitogenic on murine and human lymphocytes, induces the formation of IL-2 cell surface receptor and modulates the expression of various growth factor related genes
Tsai et al., Cancer Immunol Immunother 1994 (Mammary Neoplasms, Experimental...) : Two-color flow-cytometric analysis revealed the time dependent induction of interleukin-2 (IL-2) receptor expression on both CD4+ and CD8+ cells by prolactin
Matera et al., Life Sci 1996 (Hyperprolactinemia) : The effects of Cyclosporin ( CsA ) on IL-2 and PRL gene activation and the analysis of the intracellular signaling events downstream IL-2 and PRL receptors suggest coordinate actions of these two cytokines during T cell activation
Richards et al., Cell Immunol 1998 (HIV Infections...) : Prolactin enhances the proliferative response of lymphoid cells to both nonspecific mitogens and specific antigens and increases their production of IL-2 and interferon-gamma