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Ludwiczek et al., Eur Cytokine Netw 2001
:
Activation of caspase-3 by interferon alpha causes interleukin-16 secretion but fails to modulate activation induced cell death
Cheriyath et al., J Clin Invest 2007
(Multiple Myeloma) :
Consistent with this, IFN-alpha2b stabilized mitochondria and inhibited caspase-3 activation, which antagonized TRAIL mediated apoptosis and cytotoxicity after 24 hours of cotreatment in cell lines and in fresh myeloma cells, an effect not evident after 72 hours