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IL10 — IL12RB2
Text-mined interactions from Literome
Zhang et al., J Interferon Cytokine Res 2000
:
Corrective
effects of
interleukin-12 on age related deficiencies in IFN-gamma production and
IL-12Rbeta2 expression in virus-specific CD8+ T cells
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and
IL-10 secretion
Wu et al., Eur J Immunol 1997
:
These results suggest that Th2 cell derived cytokines can inhibit IL-12 induced biological functions by inhibiting IL-12R expression and that expression of a second subunit of the
IL-12R ( IL-12Rbeta2 ), required for the formation of high-affinity IL-12 binding sites, may be more highly
regulated by TGF-beta2 and
IL-10 than is expression of IL-12Rbeta1
Zhang et al., J Immunol 1999
(Tuberculosis) :
In M. tuberculosis stimulated peripheral blood T cells from healthy tuberculin reactors, recombinant
IL-10 and TGF-beta
reduced IL-12R beta 1 and
IL-12R beta 2 expression, as well as IFN-gamma production