Gene interactions and pathways from curated databases and text-mining

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EGF — GP2

Text-mined interactions from Literome

Hayashida et al., Int J Mol Med 1999 : EGF stimulated the mucus glycoprotein synthesis which is characterized with cell maturation, but competed with HB-EGF for cell proliferation
Roberson et al., Mol Cell Biol 2000 (Choriocarcinoma...) : Role of the cyclic AMP response element binding complex and activation of mitogen activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin
Thway et al., Biol Reprod 2002 (Choriocarcinoma) : An activator protein-1 complex mediates epidermal growth factor regulation of equine glycoprotein alpha subunit expression in trophoblast cells ... Previously, we have reported that epidermal growth factor (EGF) regulates the equine glycoprotein hormone alpha subunit promoter through a protein kinase C ( PKC ) /mitogen activated protein kinase ( MAPK ) signal transduction pathway in trophoblasts ... The current study investigates the regulatory element/factors involved in the induction of equine glycoprotein alpha subunit gene expression by EGF
Chen et al., J Invest Surg 2002 (Hypertension, Portal) : Our current study shows that the rate of incorporation of glucosamine is decreased in the PHT gastric mucosa and that EGF significantly stimulated glycoprotein synthesis in the PHT gastric mucosa
Montgomery et al., Prostate 1992 (Adenocarcinoma...) : We have demonstrated that the PSA glycoprotein is upregulated by androgens and is affected by neither epidermal growth factor nor basic fibroblast growth factor
Ye et al., Chin J Cancer 2004 (Glioma) : Leucine-rich repeats and immunoglobulin-like domains 1 ( LRIG1 ) is a kind of transmembrane glycoprotein , which is induced by epidermal growth factor (EGF) , and develops inhibitory negative feedback by specific binding with epidermal growth factor receptor (EGFR)
Kadowaki et al., J Biol Chem 1987 (Carcinoma, Squamous Cell) : In the KB cells, using phosphotyrosine-specific antibody we have found that : the receptors for insulin ( beta subunit ), IGF-I ( beta subunit ), and EGF undergo tyrosine phosphorylation as early as 10 s after addition of their respective ligands ; a 185-kDa protein is rapidly ( less than 10 s ) tyrosine phosphorylated by insulin and IGF-I through their respective receptor kinases but not EGF ; tyrosine phosphorylation of a 190-kDa glycoprotein is rapidly ( less than 10 s ) induced by EGF through EGF receptor kinase ; and tyrosine phosphorylation of a 240-kDa protein is stimulated within 30 s by all three growth factors
Yoshida et al., In Vitro Cell Dev Biol 1987 : Effect of biosynthetic human epidermal growth factor on the synthesis and secretion of mucin glycoprotein from primary culture of rabbit fundal mucosa cells ... Biosynthetic human epidermal growth factor ( Bh-EGF ) induced dose dependent synthesis and secretion of neutral mucin glycoprotein when the fundal cells isolated from rabbit stomach were cultured in serum-free medium containing Bh-EGF at concentrations as high as 10 to 100 ng/ml
Slomiany et al., J Physiol Pharmacol 1993 : The binding of EGF to buccal mucosal calcium channel receptor protein was also inhibited ( 36-41 % ) by acidic mucus glycoprotein
Chaidarun et al., Endocrinology 1994 (Pituitary Neoplasms) : In contrast, the expression of glycoprotein hormone common alpha-subunit gene in the tumor cells was reduced by EGF , T3, and 17 beta-estradiol
Koshlukova et al., Cell Signal 1995 : Cell differentiation induced by dexamethasone treatment for 3 d, however, did not significantly alter either basal or EGF stimulated GP2 release ... Basal and EGF stimulated GP2 release were similarly unaffected by caerulein, which promotes amylase secretion by a regulated route ... Furthermore, EGF stimulated GP2 release was not accompanied by significant alterations in intracellular ionic calcium levels, in contrast to the stimulatory actions of caerulein ... We conclude that EGF stimulated release of GP2 occurs via a novel secretory pathway that is neither regulated nor constitutive as currently defined
Tremblay et al., Gastroenterology 1997 : The effects of EGF ( 1, 10, and 100 ng/mL ) on DNA synthesis, glycoprotein synthesis, and lipase and pepsin activities in fetal gastric explants maintained in serum-free organ culture were determined
Solic et al., Exp Cell Res 1997 (Adenocarcinoma...) : We have characterized the morphological effects of EGF on GP2d and GP5d colon carcinoma cell lines and have compared the ability of the heparin binding EGF receptor ligand amphiregulin (AR) to elicit the same effects
Lee et al., Biochem Biophys Res Commun 1997 : EGF inhibits expression of WDNM1 and sulfated glycoprotein-2 genes in mammary epithelial cells