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HDAC7 — SP1

Text-mined interactions from Literome

Sowa et al., Cancer Res 1999 : Sp3, but not Sp1 , mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor
Zhang et al., J Biol Chem 2010 : Sp1 dependent activation of HDAC7 is required for platelet derived growth factor-BB induced smooth muscle cell differentiation from stem cells ... Moreover, we also demonstrated that knockdown of Sp1 abrogated PDGF-BB induced HDAC7 up-regulation and SMC differentiation gene expression in differentiating ES cells, although enforced expression of Sp1 alone was sufficient to increase the activity of the Hdac7 promoter and expression levels of SMC differentiation genes ... Our data suggest that Sp1 plays an important role in the regulation of Hdac7 gene expression in SMC differentiation from ES cells