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CITED2 — SETD2

Text-mined interactions from Literome

Freedman et al., Nat Struct Biol 2003 : These findings reveal that CITED2 regulates HIF-1 by competing for a hot spot on the p300 CH1 domain
Xu et al., Dev Biol 2007 : We previously detected elevated expression of HIF-1 target genes in Cited2 ( -/- ) embryonic hearts, indicating that Cited2 inhibits HIF-1 transactivation in vivo
Ng et al., BMC molecular biology 2009 (Anoxia) : This is the first report demonstrating in vivo regulation of two closely related CITED3 isogenes by HIF-1 , as well as CITED3 regulation of HIF-1 transcriptional activity in fish
Bhattacharya et al., Genes Dev 1999 (Anoxia) : Virtually all endogenous p35srj is bound to p300/CBP in vivo, and it inhibits HIF-1 transactivation by blocking the HIF-1alpha/p300 CH1 interaction ... Endogenous p35srj is up-regulated markedly by the HIF-1 activators hypoxia or deferoxamine, suggesting that it could operate in a negative-feedback loop ... In hypoxic cells, p35srj may regulate HIF-1 transactivation by controlling access of HIF-1alpha to p300/CBP, and may keep a significant portion of p300/CBP available for interaction with other transcription factors by partially sequestering and functionally compartmentalizing cellular p300/CBP