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IL15 — IL21

Text-mined interactions from Literome

D'Agostino et al., Scand J Immunol 2004 (Leishmaniasis, Visceral) : Interleukin-15 , as interferon-gamma, induces the killing of Leishmania infantum in phorbol-myristate-acetate activated macrophages increasing interleukin-12
Caprioli et al., J Immunol 2008 (Crohn Disease...) : Additionally, both IL-7 and IL-15 , but not IL-4, induce IL-21 , thus suggesting that common gamma-chain signals are not sufficient to promote IL-21 synthesis
Lindemann et al., J Biol Chem 2008 : Moreover, similar to the mutant EPO-IL-2Rbeta chimera, IL-15 and IL-21 induced IL-17RA preferentially compared with IL-2, and IL-2 but not IL-15 or IL-21 mediated prolonged activation of the PI3K p85 regulatory subunit
Hale et al., PloS one 2009 (Disease Progression...) : We report that robust changes in cytokine signal transduction occur during the progression of SLE in multiple immune cell subtypes including increased T cell responsiveness to IL-10 and ablation of Stat1 responses to IFNalpha, IFNgamma, IL-6, and IL-21 , Stat3 responses to IL-6, Stat5 responses to IL-15 , and Stat6 responses to IL-4
Nakayamada et al., Immunity 2011 : Herein, we showed interleukin-12 acting via the transcription factor STAT4 induced both Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells
Sarra et al., Mucosal Immunol 2013 (Celiac Disease) : IL-15 positively regulates IL-21 production in celiac disease mucosa ... These findings indicate that in CD, IL-15 positively regulates IL-21 production