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MAP2K4 — TNF
Pathways - manually collected, often from reviews:
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
JNKK1 (MAP2K4)
(modification, activates)
Text-mined interactions from Literome
Manna et al., Biochem Pharmacol 1999
:
Beta-lapachone also abolished
TNF induced activation of AP-1, c-Jun N-terminal kinase, and
mitogen activated protein kinase kinase ( MAPKK or MEK )
Manna et al., Oncogene 1999
:
gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited
TNF induced activation of JNK and
mitogen activated protein kinase kinase
Manna et al., J Biol Chem 2000
:
hCG abrogated the
TNF induced activation of
mitogen activated protein kinase kinase and c-Jun N-terminal kinase required for NF-kappaB and AP-1, respectively
Manna et al., J Immunol 2000
:
Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents,
inhibited the
TNF induced activation of transcription factor AP-1, and suppressed the TNF induced activation of c-Jun N-terminal kinase and
mitogen activated protein kinase kinase
Manna et al., J Immunol 2000
:
Resveratrol also inhibited the
TNF induced
activation of
mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation
Cha et al., J Pharmacol Exp Ther 2006
:
The Syk inhibitor also decreased
TNFalpha induced
mitogen activated protein kinase kinase ( MKK ) 4 phosphorylation but not MKK3 and MKK6 phosphorylation, which is consistent with its selective sparing of p38
Moriguchi et al., EMBO J 1997
:
MKK7 is activated strongly by tumour necrosis factor alpha (TNFalpha) as well as by environmental stresses, whereas
SEK1/MKK4 is not
activated by
TNFalpha
Manna et al., J Biol Chem 1998
:
In addition, Mn-SOD blocked the
TNF mediated activation of activated protein-1, stress activated c-Jun protein kinase, and
mitogen activated protein kinase kinase