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PTK2B — TNF

Text-mined interactions from Literome

Chauhan et al., Oncogene 1999 (Multiple Myeloma) : Related Adhesion Focal Tyrosine Kinase ( RAFTK ; also known as Pyk2 ), is a member of the Focal Adhesion Kinase ( FAK ) subfamily and is activated by TNF alpha , UV light and increases in intracellular calcium levels
Satoh et al., Gastroenterology 2005 (Acute Disease...) : Tumor necrosis factor-alpha increased the tyrosine phosphorylation of proline-rich tyrosine kinase 2 in acinar cells ... The broad-spectrum protein kinase C inhibitor and the Src kinase inhibitor both inhibited tumor necrosis factor-alpha induced proline-rich tyrosine kinase 2 phosphorylation, but at different tyrosine residues ... Furthermore, with antisense transfections, we showed that protein kinase C delta and, but not proline-rich tyrosine kinase 2 , mediate tumor necrosis factor alpha induced nuclear factor-kappaB activation ... Tumor necrosis factor-alpha activates proline-rich tyrosine kinase 2 to cause cytoskeletal disorganization and nuclear factor-kappaB to cause inflammatory response, and it triggers cell death signaling through divergent mechanisms mediated by protein kinase C