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REL — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Martin et al., J Biol Chem 2000
:
Thus, TNFalpha induced phosphorylation of Ser-471 seems to be absolutely necessary for
TNFalpha activation of
c-Rel
Kang et al., J Pharmacol Exp Ther 2002
:
Silymarin also inhibited
tumor necrosis factor-alpha induced
NF-kappaB/Rel activation , whereas okadaic acid induced NF-kappaB/Rel activation was not affected
Kang et al., FEBS Lett 2003
:
Moreover, silymarin suppressed the
TNF-alpha induced DNA binding of
NF-kappaB/Rel in HUVECs
Morello et al., J Immunol 2006
:
IL-1beta and TNF-alpha rapidly activated p50 and p65, but not
C-Rel , RelB, or p52, and both IL-1beta- and
TNF-alpha stimulated A2AR expression was
inhibited by the IkappaB kinase 2 inhibitor AS602868 in a concentration dependent manner
Wang et al., J Biol Chem 2007
(Thrombosis) :
By electrophoretic mobility shift assay analyses,
TNF-alpha and lipopolysaccharide
induce strong p65/p50 and
p65/c-Rel heterodimer binding to both NF-kappaB and TF-kappaB probes
Jahnke et al., FEBS Lett 1994
(Melanoma) :
Synergistic activation of intercellular adhesion molecule 1 ( ICAM-1 ) by
TNF-alpha and IFN-gamma is
mediated by p65/p50 and
p65/c-Rel and interferon-responsive factor Stat1 alpha ( p91 ) that can be activated by both IFN-gamma and IFN-alpha
Beg et al., Oncogene 1994
:
Activation of multiple NF-kappa
B/Rel DNA binding complexes by
tumor necrosis factor
Jahnke et al., Immunobiology 1995
(Melanoma) :
Using electrophoretic mobility shift assays and specific antibodies we observed that the NF-kappa B like sequence at -187 bound both p65/p50 and
p65/c-Rel in the
presence of
TNF-alpha , while the interferon responsive region at -75 bound Stat1 alpha ( p91 )
Kochetkova et al., J Clin Invest 1997
(Leukemia, Myelomonocytic, Chronic) :
The constitutive and
TNFalpha induced
NF-kappaB/Rel complexes were identical and were composed mainly of p50 and c-Rel proteins ... These results indicate that the aberrant, constitutive GM-CSF gene activation in JMML is maintained by
TNFalpha mediated activation of
NF-kappaB/Rel proteins
Tobin et al., Proc Natl Acad Sci U S A 1998
:
Therefore, UVB induced
activation of
Rel proteins via
TNF receptor 1, independent of ligand activation, is a key component in the UV response in keratinocytes