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PPM1D — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lu et al., Mol Cell 2004
:
The wild-type
p53 induced phosphatase
PPM1D ( or Wip1 ) is a serine/threonine phosphatase that is transcriptionally upregulated by p53 following ultraviolet and ionizing radiation
Lu et al., Cell cycle (Georgetown, Tex.) 2004
(Breast Neoplasms...) :
PPM1D may
inhibit p53 activity through inactivating dephosphorylation of the p38 MAP kinase
Lu et al., Cell cycle (Georgetown, Tex.) 2005
:
Because PPM1D is transcriptionally activated by p53 in response to DNA damage, PPM1D may serve as a critical component of a p53 negative feedback regulatory loop since it now appears that
PPM1D can
inhibit p53 activity by at least four different molecular mechanisms
Lu et al., Cancer Cell 2007
(Osteosarcoma) :
Here we show that the wild-type
p53 induced phosphatase 1 ( Wip1 ), or
PPM1D , downregulates p53 protein levels by stabilizing Mdm2 and facilitating its access to p53
Pärssinen et al., Cancer Genet Cytogenet 2008
(Breast Neoplasms) :
Our findings demonstrate that
PPM1D is involved in the regulation of cell proliferation in breast cancer in a
p53 dependent manner and that overexpression of PPM1D contributes to malignant phenotype by promoting sustained cell growth and cell survival
Nguyen et al., DNA repair 2010
:
Therefore, we investigated whether the serine/threonine wild-type
p53 induced phosphatase 1 (
WIP1/PPM1D ) might regulate NER