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ATXN7 — TRRAP
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
ATXN7
→
TRRAP
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TRRAP
—
ATXN7
(physical association, affinity chromatography technology)
Demény et al., PloS one 2007
-
IRef Biogrid Interaction:
TRRAP
—
ATXN7
(physical association, affinity chromatography technology)
Zhao et al., Mol Cell 2008
-
IRef Biogrid Interaction:
TRRAP
—
ATXN7
(physical association, affinity chromatography technology)
Palhan et al., Proc Natl Acad Sci U S A 2005
-
IRef Biogrid Interaction:
TRRAP
—
ATXN7
(physical association, affinity chromatography technology)
Helmlinger et al., PLoS Biol 2006*
-
MIPS CORUM TFTC complex (TATA-binding protein-free TAF-II-containing complex):
TFTC complex (TATA-binding protein-free TAF-II-containing complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-TADA3-TAF10-TAF12-TAF2-TAF4-TAF5-TAF5L-TAF6-TAF6L-TAF7-TAF9-TRRAP)
Brand et al., J Biol Chem 1999
-
MIPS CORUM TFTC complex (TATA-binding protein-free TAF-II-containing complex):
TFTC complex (TATA-binding protein-free TAF-II-containing complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-TADA3-TAF10-TAF12-TAF2-TAF4-TAF5-TAF5L-TAF6-TAF6L-TAF7-TAF9-TRRAP)
Cavusoglu et al., Proteomics 2003
-
MIPS CORUM TFTC complex (TATA-binding protein-free TAF-II-containing complex):
TFTC complex (TATA-binding protein-free TAF-II-containing complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-TADA3-TAF10-TAF12-TAF2-TAF4-TAF5-TAF5L-TAF6-TAF6L-TAF7-TAF9-TRRAP)
Helmlinger et al., Hum Mol Genet 2004
-
MIPS CORUM TFTC complex (TATA-binding protein-free TAF-II-containing complex):
TFTC complex (TATA-binding protein-free TAF-II-containing complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-TADA3-TAF10-TAF12-TAF2-TAF4-TAF5-TAF5L-TAF6-TAF6L-TAF7-TAF9-TRRAP)
Helmlinger et al., Hum Mol Genet 2004
-
MIPS CORUM TFTC complex (TATA-binding protein-free TAF-II-containing complex):
TFTC complex (TATA-binding protein-free TAF-II-containing complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-TADA3-TAF10-TAF12-TAF2-TAF4-TAF5-TAF5L-TAF6-TAF6L-TAF7-TAF9-TRRAP)
Wieczorek et al., Nature 1998
-
MIPS CORUM TFTC complex (TATA-binding protein-free TAF-II-containing complex):
TFTC complex (TATA-binding protein-free TAF-II-containing complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-TADA3-TAF10-TAF12-TAF13-TAF2-TAF4-TAF5-TAF5L-TAF6-TAF6L-TAF7-TAF9-TRRAP)
Brand et al., Science 1999
-
MIPS CORUM STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex):
STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-SUPT7L-TADA1-TADA3-TAF10-TAF12-TAF5L-TAF6L-TAF9-TRRAP)
Helmlinger et al., Hum Mol Genet 2004
-
MIPS CORUM TFTC complex (TATA-binding protein-free TAF-II-containing complex):
TFTC complex (TATA-binding protein-free TAF-II-containing complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-TADA3-TAF10-TAF12-TAF2-TAF4-TAF5-TAF5L-TAF6-TAF6L-TAF7-TAF9-TAF9B-TRRAP)
Frontini et al., Mol Cell Biol 2005
-
IRef Corum Interaction:
Complex of 145 proteins
(association, anti bait coimmunoprecipitation)
Cavusoglu et al., Proteomics 2003
-
IRef Corum Interaction:
Complex of 52 proteins
(association, anti bait coimmunoprecipitation)
Frontini et al., Mol Cell Biol 2005
-
IRef Corum Interaction:
Complex of 14 proteins
(association, anti bait coimmunoprecipitation)
Helmlinger et al., Hum Mol Genet 2004
-
IRef Corum Interaction:
Complex of 69 proteins
(association, affinity chromatography technology)
Brand et al., Science 1999
-
IRef Hprd Interaction:
TRRAP
—
ATXN7
(in vivo)
Helmlinger et al., Hum Mol Genet 2004
-
IRef Intact Interaction:
Complex of 21 proteins
(association, anti bait coimmunoprecipitation)
Helmlinger et al., Hum Mol Genet 2004
-
IRef Intact Interaction:
TRRAP
—
ATXN7
(physical association, anti bait coimmunoprecipitation)
Helmlinger et al., Hum Mol Genet 2004
Text-mined interactions from Literome
Liu et al., J Biol Chem 2003
:
c-Myc transformation domain recruits the human
STAGA complex and
requires TRRAP and GCN5 acetylase activity for transcription activation
Palhan et al., Proc Natl Acad Sci U S A 2005
(Retinal Degeneration...) :
Here, we report that
ataxin-7 is an integral component of the mammalian STAGA ( SPT3-TAF9-ADA-GCN5 acetyltransferase ) transcription coactivator complex, interacts directly with the GCN5 histone acetyltransferase component of STAGA, and
mediates a direct interaction of
STAGA with the CRX ( cone-rod homeobox ) transactivator of photoreceptor genes
Liu et al., Mol Cell Biol 2008
:
STAF65gamma is
required for
SPT3/STAGA interaction with core Mediator and for MYC recruitment of SPT3, TAF9, and core Mediator components to the TERT promoter but is dispensable for MYC recruitment of TRRAP, GCN5, and p300 and for acetylation of nucleosomes and loading of TFIID and RNA polymerase II on the promoter