◀ Back to TLR4
IL1B — TLR4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Frantz et al., J Clin Invest 1999
(Heart Failure...) :
TLR4 expression levels in cardiac myocytes and in coronary microvascular endothelial cells could be
enhanced by either LPS or
IL-1beta , an effect inhibited by the oxygen radical scavenger PDTC
Laflamme et al., FASEB J 2001
:
In contrast to the strong up-regulation of the gene encoding mCD14 during endotoxemia, neither LPS nor
IL-1beta caused a convincing increase in the
TLR4 mRNA levels across the CNS
Supajatura et al., J Immunol 2001
(Acute Disease...) :
Using BMMCs from the genetically TLR4 mutated strain C3H/HeJ, we demonstrated that functional
TLR4 was
required for a full responsiveness of BMMCs to produce inflammatory cytokines (
IL-1beta , TNF-alpha, IL-6, and IL-13 ) by LPS stimulation
Netea et al., J Infect Dis 2002
(Candidiasis) :
Production of tumor necrosis factor (TNF) and interleukin (IL)-1alpha and
IL-1beta by mouse macrophages in response to C. albicans stimulation was not
affected by
TLR4 , and the candidacidal capacities of the neutrophils and macrophages of C3H/HeJ mice were normal
Paterson et al., J Immunol 2003
(Burns...) :
Using an in vivo injury model, we demonstrate that injury significantly increased TLR2- and
TLR4 induced
IL-1beta , IL-6, and TNF-alpha production by spleen cells
Prince et al., Am J Pathol 2004
(Inflammation) :
The
role of
interleukin-1beta in direct and
toll-like receptor 4-mediated neutrophil activation and survival
Banus et al., Infect Immun 2006
(Genetic Predisposition to Disease...) :
Functional
Tlr4 is
essential for an efficient
IL-1-beta , TNF-alpha, and IFN-gamma response ; efficient clearance of bacteria from the lung ; and reduced lung pathology
Li et al., J Immunol 2007
:
Alum induced
IL-1beta and IL-18 production was not
due to enhancement of
TLR signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion
Wrann et al., J Immunol 2007
(Sepsis) :
In addition, PI3K inhibition resulted in strongly elevated
TLR-4 mediated generation of
IL-1beta and IL-8 in neutrophils when these cells were co-stimulated with C5a
Dinarello et al., Immunity 2007
(Inflammation) :
Secretion of the proinflammatory cytokine
IL-1beta requires caspase-1 and
Toll-like receptor ( TLR ) signaling
Kim et al., Immunol Lett 2007
(Arthritis, Rheumatoid...) :
TLR stimulation of RA-FLS also
induced the production of
IL-1beta and TNF-alpha to a lesser extent ; however, it had no effect on IL-17 production ... Inhibition of
TLR induced
IL-1beta production, which partially reversed the upregulation of RANKL induced by TLR ligands
Bobacz et al., Arthritis Rheum 2007
:
IL-1beta mRNA expression was
increased by
TLR-4 activation, whereas expression of aggrecan and type II collagen was significantly decreased
Ferwerda et al., J Leukoc Biol 2007
(Crohn Disease) :
TLR induced TNF-alpha,
IL-1beta , and IL-10 production is mediated through MyD88, whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta
Villacres et al., J Viral Hepat 2008
(Hepatitis C, Chronic) :
To a lesser extent, tumour necrosis factor-alpha and
IL-1beta responses to
TLR stimulation were also compromised
Shoma et al., Infect Immun 2008
:
When macrophages were stimulated with rPLY, the production of IL-1alpha,
IL-1beta , and IL-18 was strongly induced in a
TLR4 dependent manner, whereas lipopolysaccharide, a canonical TLR4 agonist, hardly induced these cytokines
Blanco et al., J Neurochem 2008
:
Here we show that stimulation of astrocytes with
IL-1beta , lipopolysaccharide or ethanol ( 10 and 50 mM ),
triggers the translocation of IL-1RI and/or
TLR4 into lipid rafts caveolae enriched fractions, promoting the recruitment of signalling molecules ( phospho-IL-1R associated kinase and phospho-extracellular regulated-kinase ) into these microdomains
Cha et al., Ann Thorac Surg 2008
(Myocardial Reperfusion Injury) :
This study examined whether
TLR4 regulates TNF-alpha and interleukin
(IL)-1beta peptide production during global ischemia/reperfusion and whether TLR4 signaling influences postischemic cardiac function through TNF-alpha and IL-1beta
Maelfait et al., J Exp Med 2008
(Inflammation) :
These results implicate a novel role for caspase-8 in the production of biologically active
IL-1beta in
response to TLR3 and
TLR4 stimulation
Netea et al., Expert Opin Biol Ther 2008
(Inflammation) :
Monocytes can release active
IL-1 beta upon
stimulation with
TLR ligands alone
Mencarelli et al., Am J Physiol Heart Circ Physiol 2009
(Atherosclerosis...) :
FXR activation by natural and synthetic ligands in these cell types attenuated
IL-1beta , IL-6, and TNF-alpha gene induction in
response to
Toll-like receptor 4 activation by LPS
Mishra et al., Immunobiology 2009
:
Our findings suggest that RAE
induces TLR-4 expression and intracellular granzyme-B in treated splenocytes while RAE stimulated
IL-1beta , IL-6, and TNF-alpha in human PBMCs
van de Veerdonk et al., J Infect Dis 2009
(Inflammation) :
The transcription of
IL-1beta was
induced through mannose receptor ( MR ), Toll-like receptor (TLR) 2, and dectin-1 but not through
TLR4 and TLR9
Hurst et al., Immunobiology 2009
(Antiphospholipid Syndrome) :
Determination of expression-levels using real-time RT-PCR showed significantly augmented
TLR dependent
IL-1beta and caspase-1 expression
Jung et al., Immunol Lett 2009
(Arthritis, Experimental...) :
These data show that TLR2,
TLR4 , and TLR6 ligation synergistically
stimulates the production of TNF-alpha and
IL-1beta in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model
Jie Zhao et al., Innate Immun 2009
(Aspergillosis...) :
Aspergillus fumigatus keratitis developed in Wistar rats, as evidenced by high SLE scores, influx of polymorphonuclear leukocytes ( PMNs ),
activation of TLR2 and
TLR4 , and production of
IL-1beta and IL-10 over controls
Lamkanfi et al., J Biol Chem 2009
(Inflammation) :
IL-1beta secretion further
required the
Toll-like receptor ( TLR ) adaptors MyD88 and TRIF, and partially relied on TLR2
Kleinnijenhuis et al., Eur J Immunol 2009
:
In contrast,
TLR4 , TLR9 and TLR1 receptors are not
involved in
IL-1beta induction
Ward et al., Immunology 2009
(Inflammation) :
TLR4 induced
IL-1beta production by monocytes was increased by TLR4 dependent endothelial activation in coculture, and was associated with increased monocyte CD14 expression
Wu et al., Toxicol Lett 2009
(Inflammation) :
This study used RNA interference techniques to show that
TLR4 can
mediate LPS induced macrophage activations of
IL-1beta and IL-6 gene expression, chemotaxis, phagocytosis, and oxidative ability
Böni-Schnetzler et al., Endocrinology 2009
:
FFA induced
IL-1beta and KC expression in mouse islets was completely
dependent on the
IL-1R/Toll-like receptor ( TLR ) docking protein Myd88 and partly dependent on TLR2 and -4
Deopurkar et al., Diabetes Care 2010
(Inflammation) :
Indexes of inflammation including nuclear factor-kappaB (NF-kappaB) binding, and the expression of SOCS3, tumor necrosis factor-alpha (TNF-alpha), and interleukin
(IL)-1beta in MNCs, increased significantly after glucose and cream intake, but
TLR-4 expression and plasma LPS concentrations
increased only after cream intake
Lee et al., Journal of inflammation (London, England) 2010
:
IL-1beta potently induced NF-kappaB activation in CaCo-2 cells, but did not
induce TLR-4 expression
Mayer-Barber et al., J Immunol 2010
(Tuberculosis, Pulmonary) :
Caspase-1 independent
IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not
require TLR signaling in vivo