Gene interactions and pathways from curated databases and text-mining

◀ Back to IFNG

IFNG — IL11

Text-mined interactions from Literome

Lalain et al., Diabetologia 1999 (Diabetes Mellitus, Type 1) : During proliferation in response to islet cells, interleukin-10 increased 43-fold ( p < 0.01 ) but interferon-gamma increased only slightly
Filice et al., Infect Immun 1999 (Cytomegalovirus Infections...) : As pulmonary inflammation developed, levels of cytokine mRNAs for gamma interferon ( IFN-gamma ), interleukin-2 (IL-2), IL-4, and IL-10 increased in bronchoalveolar lavage (BAL) cells or lung tissue, and the level of IFN-gamma protein increased in BAL fluid
Sugaya et al., J Invest Dermatol 1999 : Interleukin-18 or interleukin-12 alone did not induce interferon-gamma production by dendritic epidermal T cells ... Thus, this study suggests that interleukin-18 and interleukin-12 produced by keratinocytes and Langerhans cells regulate interferon-gamma production by dendritic epidermal T cells and thus may play important parts in the regulation of immune responses in skin associated lymphoid tissues
Elhofy et al., Infect Immun 1999 (Salmonella Infections, Animal) : It has recently been suggested that, interleukin-18 (IL-18), in addition to IL-12, contributes to the induction of IFN-gamma following infection
Dybing et al., Infect Immun 1999 (Salmonella Infections, Animal) : As such, several different cytokines including, interleukin-12 (IL-12) and IL-18, can induce IFN-gamma
Francis et al., Immunology 2000 (Arthritis, Experimental...) : Peptide inhalation induces the production of Th1-type cytokines ( interferon-gamma ) whereas intraperitoneal immunization leads to the production of Th2-type cytokines ( interleukin-4, interleukin-5 and interleukin-10 ) by splenic T cells upon stimulation with peptide
Wang et al., J Immunol 2000 (Pulmonary Eosinophilia) : In addition, IL-11 did not augment IFN-gamma production demonstrating that the inhibitory effects of IL-11 were not due to a shift toward Th1 inflammation
Koh et al., J Clin Immunol 2001 (Asthma...) : As a correlate, interleukin-4 (IL-4) production significantly decreased and interferon-gamma (IFN-gamma) slightly increased , resulting in a markedly decreased ratio of IL-4-IFN-gamma in OVA presensitized rats with BCG infection
Kitagawa et al., J Rheumatol 2001 (Arthritis, Rheumatoid) : Interferon-gamma enhances interleukin 12 production in rheumatoid synovial cells via CD40-CD154 dependent and independent pathways
Sutherland et al., Immunol Rev 2001 : Although ULBPs alone activate multiple signaling pathways and induce modest cytokine production, ULBPs synergize strongly with interleukin-12 for production of interferon-gamma by NK cells
Puliti et al., Arthritis Rheum 2002 (Arthritis, Infectious...) : The beneficial effect of interleukin-12 on arthritis induced by group B streptococci is mediated by interferon-gamma and interleukin-10 production
Malmgaard et al., J Gen Virol 2003 (Herpes Simplex) : Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2
Tomoda et al., Biochim Biophys Acta 1992 (Leukemia, Monocytic, Acute) : Inhibition of interferon-gamma- and phorbol ester induced HLA-DR and interleukin-1 production by the expression of a transfected poly ( ADP-ribose ) synthetase gene in human leukemia THP-1 cells
Imanishi et al., Hepatogastroenterology 2003 (Carcinoma, Hepatocellular...) : We evaluated interleukin-12 induced interferon-gamma production as one of the immunological markers of patients with chronic liver diseases ... The level of interleukin-12 induced interferon-gamma production by peripheral blood mononuclear cells in the patients with hepatocellular carcinoma was significantly lower than that in the patients with liver cirrhosis which is thought to be a premalignant state
Murray et al., Infect Immun 2003 (Leishmaniasis, Visceral) : Optimal killing triggered by both anti-CD40 and anti-CTLA-4 required endogenous IFN-gamma and involved interleukin 12
dos Santos et al., Vet Immunol Immunopathol 2004 (Dog Diseases...) : Recombinant single-chain canine interleukin 12 induces interferon gamma mRNA expression in peripheral blood mononuclear cells of dogs with visceral leishmaniasis
Ethuin et al., Lab Invest 2004 : Human neutrophils produce interferon gamma upon stimulation by interleukin-12
Loughlin et al., Immunology 1992 : Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide : effects on interferon-gamma induced activation
Fernández-Lago et al., J Med Microbiol 2005 (Brucellosis) : Following infection, interleukin-18 (IL-18) may contribute , in association with IL-12, to optimal IFN-gamma production
Ellermann-Eriksen et al., Virology journal 2005 (Herpes Simplex) : In the next wave, interleukin (IL)-12 together with the above and other cytokines induce production of IFN-gamma in mainly NK cells
Wood et al., Eur J Pediatr 2005 (Hypersensitivity) : Defects in interferon-gamma receptor/interleukin-12 receptor responses are not sufficient to cause clinical allergic disease
Rezende et al., Int Endod J 2005 : The cellular viability and the production of tumour necrosis factor-alpha, interleukin (IL)-12 and IL-10 in response to stimulation with interferon-gamma and Fusobacterium nucleatum or Peptostreptococcus anaerobius were evaluated
Kriegel et al., Immunology 2006 : Interleukin-4 supports interleukin-12 induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells
Al-Attiyah et al., Clin Exp Immunol 2006 (Tuberculosis) : Among the cytokines studied, interleukin (IL)-10 and IL-12 were not detected at all, whereas low levels of interferon (IFN)-gamma after 96 h ( 0.4 IU/ml ) and tumour necrosis factor (TNF)-alpha after 48 ( 135 pg/ml ) and 96 h ( 47 pg/ml ) of culture were detected in the supernatants of whole blood infected with M. tuberculosis
Price et al., Immunology 2007 : Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of interferon-gamma in response to stimulation with interleukin-12 and -18
Ghiringhelli et al., Immunol Rev 2006 (Disease Progression...) : This review summarizes the findings showing that Tregs suppress NK cell effector functions in vitro and in vivo, i.e. homeostatic proliferation, cytotoxicity, and interleukin-12 mediated IFN-gamma production
Tsuda et al., Cancer Res 2007 (Ovarian Neoplasms) : RNAs in ISMMC stimulate immature dendritic cells to secrete interleukin 12 and induce IFN-gamma in peripheral blood mononuclear cells
Ebert et al., Immunology 2008 : Massive interleukin-12 induced interferon-gamma production by interleukin-15 stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor
Lonial et al., Exp Hematol 2008 : The immunostimulatory effect of DC1 required DC-to-T-cell contact, and induced interleukin-12 secretion, while DC2 cells induced interferon-gamma secretion
Kubera et al., J Pharmacol Sci 2008 (Cocaine-Related Disorders...) : Cocaine self administered for 18 days induced a significant increase in spleen weight, plasma corticosterone levels, interleukin (IL)-10 , and tumor necrosis factor-alpha production, while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and interferon-gamma production by splenic lymphocytes were not altered
Campos Alberto et al., Immunology 2009 : Differential effects of tumour necrosis factor-alpha and interleukin-12 on isopentenyl pyrophosphate stimulated interferon-gamma production by cord blood Vgamma9 T cells
Vesosky et al., Infect Immun 2009 (Tuberculosis) : In addition, M. tuberculosis induced IFN-gamma production by CD8 T cells isolated from naïve old mice was major histocompatibility complex class I independent but was dependent on interleukin-12p70 , confirming an innate role of CD8 T cells during M. tuberculosis infection
Bill et al., Mol Cancer Ther 2009 (Melanoma) : Finally, stimulation of natural killer ( NK ) cells with curcumin reduced the level of interleukin-12 induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets
Armstrong-James et al., J Infect Dis 2009 (Pulmonary Aspergillosis) : Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis
Nagineni et al., Biochem Biophys Res Commun 2010 : IL-11 expression in retinal and corneal cells is regulated by interferon-gamma ... IFN-gamma significantly inhibited TNF-alpha and IL-1 induced IL-11 secretion and inhibitors of JAK-STAT pathway reversed this inhibition ... RT-PCR analysis confirmed the effects of IL-1, TNF-alpha, IFN-gamma and TGF-beta on IL-11 secretion at mRNA levels
Beldi et al., Hepatology 2010 (Reperfusion Injury) : Specifically, ATPgammaS ( a nonhydrolyzable ATP analog ) inhibits secretion of interferon gamma by NK cells in response to interleukin-12 and interleukin-18, providing a mechanistic link between CD39 deletion and altered cytokine secretion
Reiner et al., J Clin Invest 1990 (Leishmaniasis, Visceral) : Interferon-gamma prevents parasite induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1
Xie et al., Int J Oncol 1993 : L929 parental cells and L929 cells selected for resistance to tumor necrosis factor ( TNF-alpha ) were incubated in vitro with various concentrations of TNF-alpha, interleukin-1 , and lipopolysaccharide (LPS) in the presence or absence of mouse interferon-gamma (IFN-gamma)
Miossec et al., J Immunol 1986 : Immune interferon enhances the production of interleukin 1 by human endothelial cells stimulated with lipopolysaccharide
Gerrard et al., J Immunol 1987 : Differential effects of interferon-alpha and interferon-gamma on interleukin 1 secretion by monocytes
Haq et al., Immunobiology 1988 : Failure of hydrocortisone to suppress the interferon-gamma induced augmentation of interleukin 1 secretion of aged human monocytes
Auböck et al., Arch Dermatol Res 1985 : HLA-DR expression was induced by the supernatants and human recombinant interferon-gamma ( rIFN-gamma ), whereas recombinant interferon-alpha 2, interleukin-2 and non-recombinant human interferon-beta had no such effect
Hunter et al., Eur J Immunol 1995 (Toxoplasmosis, Animal) : Transforming growth factor-beta inhibits interleukin-12 induced production of interferon-gamma by natural killer cells : a role for transforming growth factor-beta in the regulation of T cell independent resistance to Toxoplasma gondii
Ogata et al., Br J Haematol 1995 (Myelodysplastic Syndromes) : Effects of interleukin-12 on natural killer cell cytotoxicity and the production of interferon-gamma and tumour necrosis factor-alpha in patients with myelodysplastic syndromes
Nakamura et al., Infect Immun 1993 : The factor, interleukin-2 , anti-CD3 MAb, or ConA alone induced a trace of or no detectable IFN-gamma in these cells
Sanchez-Bueno et al., Biochem Biophys Res Commun 1996 (Fibrosarcoma) : Interferon-gamma dependent expression of inducible nitric oxide synthase, interleukin-12 , and interferon-gamma inducing factor in macrophages elicited by allografted tumor cells
Libraty et al., J Clin Invest 1997 (Leprosy) : Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy
Trinchieri et al., Curr Opin Hematol 1997 : If interleukin-12 and interleukin-12 induced interferon gamma are present during early T-cell expansion in response to antigen, T-helper type-1 cell generation is favored and generation of T-helper type-2 cells is inhibited
Gollob et al., Eur J Immunol 1997 : Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
Hunter et al., Eur J Immunol 1997 : Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma inducing factor on the production of interferon-gamma by natural killer
Gross et al., Infect Immun 1998 : Expression of iNOS, interleukin-6 , and tumor necrosis factor alpha (TNF-alpha) mRNAs was induced in both c-Brucella- and ops-Brucella infected cells and was strongly potentiated by IFN-gamma
Taki et al., Clin Exp Immunol 1998 (Arthritis, Rheumatoid) : In the present study we examined the capacity of fresh rheumatoid synovial cells ( fresh RSC ) to produce IL-11, and the effect of indomethacin, dexamethasone and IFN-gamma on IL-11 production ... IFN-gamma inhibited the production of IL-11 from IL-1alpha stimulated cultured rheumatoid synovial fibroblasts, although IFN-gamma did not inhibit the production of IL-11 by fresh RSC ... These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma , and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA
Hayes et al., Blood 1998 (Cell Transformation, Viral) : Interferon-gamma dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus transformed lymphoblastoid cells
Baden et al., J Biol Chem 1998 : The amino-terminal domain of STAT4 ( STAT4 ( 1-124 ) ) is required for cooperative binding interactions between STAT4 dimers and activation of interferon-gamma transcription in response to interleukin-12
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Byl et al., J Interferon Cytokine Res 1998 (Acquired Immunodeficiency Syndrome) : Bacterial extract OM85-BV induces interleukin-12 dependent IFN-gamma production by human CD4+ T cells
Hodge-Dufour et al., Proc Natl Acad Sci U S A 1998 (Inflammation) : Inhibition of interferon gamma induced interleukin 12 production : a potential mechanism for the anti-inflammatory activities of tumor necrosis factor