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RUNX2 — SETD2

Text-mined interactions from Literome

Kwon et al., J Cell Biochem 2011 : In normoxia, Runx2 also dramatically increased HIF-1a protein ... In all cases, the Runx2 response was inhibited by siRNA mediated suppression of HIF-1a and completely blocked by the HIF-1a inhibitor, echinomycin
Lee et al., J Biol Chem 2012 : Runx2 caused the accumulation of HIF-1a protein in ATDC5 chondrocytes and HEK293 cells under normoxic conditions ... Runx2 also increased the nuclear translocation of HIF-1a when coexpressed in HEK293 cells and interacted with HIF-1a at the oxygen dependent degradation domain ( ODDD ) ... These results suggest that Runx2 stabilizes HIF-1a by binding to ODDD to block the interaction between von Hippel-Lindau protein and HIF-1a