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CHMP3 — EGFR

Pathways - manually collected, often from reviews:

• NCI Pathway Database Internalization of ErbB1: Vps24 (CHMP3) → EGFR/EGFR/EGF/EGF complex (EGFR-EGF) (translocation, activates)
  Morino et al., Exp Cell Res 2004, Sigismund et al., Proc Natl Acad Sci U S A 2005, Bache et al., Mol Biol Cell 2006*, Oved et al., J Biol Chem 2006, Raiborg et al., Exp Cell Res 2008*, Roxrud et al., J Cell Biol 2008
  Evidence: physical interaction
• NCI Pathway Database Internalization of ErbB1: Vps24 (CHMP3) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (translocation, activates)
  Burke et al., Mol Biol Cell 2001, Ravid et al., J Biol Chem 2004, Mosesson et al., Dev Cell 2009, Levkowitz et al., Genes Dev 1998
  Evidence: assay

Text-mined interactions from Literome

Bache et al., Mol Biol Cell 2006 : The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
Langelier et al., J Virol 2006 : Consistent with its expected role in MVB vesicle formation, ( i ) human ESCRT-II localized to endosomal membranes in a VPS4 dependent fashion and ( ii ) depletion of EAP20/ESCRT-II and CHMP6/ESCRT-III inhibited lysosomal targeting and downregulation of the epidermal growth factor receptor , albeit to a lesser extent than depletion of TSG101/ESCRT-I