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CCND1 — POLDIP2
Text-mined interactions from Literome
Page et al., Am J Physiol Lung Cell Mol Physiol 2001
:
We tested whether
p38 regulates
cyclin D1 expression via inhibition of extracellular signal regulated kinase ( ERK ) activation ... These data are consistent with the notion that
p38alpha negatively
regulates cyclin D1 expression via an ERK independent pathway
Cloninger et al., Mol Cancer Ther 2011
(Brain Neoplasms...) :
Here, we show that both genetic and pharmacologic inhibition of
SAPK2/p38 in glioblastoma multiforme cells significantly
reduces rapamycin induced IRES mediated translation initiation of
cyclin D1 and c-MYC, resulting in increased G ( 1 ) arrest in vitro and inhibition of tumor growth in xenografts