Gene interactions and pathways from curated databases and text-mining

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CCND1 — POLDIP2

Text-mined interactions from Literome

Page et al., Am J Physiol Lung Cell Mol Physiol 2001 : We tested whether p38 regulates cyclin D1 expression via inhibition of extracellular signal regulated kinase ( ERK ) activation ... These data are consistent with the notion that p38alpha negatively regulates cyclin D1 expression via an ERK independent pathway
Cloninger et al., Mol Cancer Ther 2011 (Brain Neoplasms...) : Here, we show that both genetic and pharmacologic inhibition of SAPK2/p38 in glioblastoma multiforme cells significantly reduces rapamycin induced IRES mediated translation initiation of cyclin D1 and c-MYC, resulting in increased G ( 1 ) arrest in vitro and inhibition of tumor growth in xenografts