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GSK3B — NGF

Text-mined interactions from Literome

Crowder et al., J Biol Chem 2000 : Stimulation with NGF resulted in PI 3-kinase dependent phosphorylation of GSK-3 beta and inhibition of its protein kinase activity, indicating that GSK-3 beta is targeted by PI 3-kinase/Akt in these neurons ... However, expression of neither Frat1, kinase-deficient GSK-3 beta , nor GSK-3 binding protein inhibited NGF withdrawal induced death
Goold et al., J Neurochem 2003 : Chick ciliary ganglion neurons in culture lack TrkA receptors but express p75NTR and also fail to show NGF dependent GSK3beta phosphorylation of MAP1B, whereas in rat superior cervical ganglion neurons in culture, NGF activation of TrkA receptors elicits GSK3beta phosphorylation of MAP1B ... These results suggest that the activation of GSK3beta by NGF is mediated through the TrkA tyrosine kinase receptor and not through p75NTR receptors
Goold et al., Mol Cell Neurosci 2005 (MAP Kinase Signaling System) : In pheochromocytoma 12 ( PC12 ) cells and sympathetic neurons, nerve growth factor (NGF) engagement with the tropomyosin related tyrosine kinase (TrkA) receptor activates the serine/threonine kinase glycogen synthase kinase 3beta ( GSK3beta ), enabling it to phosphorylate the microtubule associated protein 1B ( MAP1B )