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GLI3 — PTHLH
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Koziel et al., Development 2005
:
Our results suggest a model in which the Ihh/Gli3 system regulates two distinct steps of chondrocyte differentiation : ( 1 ) the switch from distal into columnar chondrocytes is repressed by Gli3 in a PTHrP independent mechanism ; ( 2 ) the transition from proliferating into hypertrophic chondrocytes is regulated by
Gli3 dependent expression of
PTHrP
Mau et al., Dev Biol 2007
:
PTHrP negatively regulated Gli mediated transcription in cell cultures, and
regulated the level of the repressor form of
Gli3 in a PKA dependent manner