Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
IFNG
→
HRH2
(increases, IFNG Activity)
Kohka et al., J Immunol 2000* Evidence: The stimulatory or inhibitory effects of histamine on cytokine production were all antagonized by H2 receptor antagonists ranitidine and famotidine in a concentration-dependent manner, but not by H1 and H3 receptor antagonists. Selective H2 receptor agonists, 4-methylhistamine and dimaprit, mimicked the effects of histamine on five kinds of cytokine production.