Liu et al., Mol Pharmacol 2008
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D ( 3 ) -IC3, which does not bind S100B, does not contain this motif ; and 5 ) coexpression of S100B in D ( 2 ) receptor expressing 293 cells selectively increased D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of adenylate cyclase Fanò et al., FEBS Lett 1988
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S-100b inhibits the adenylate cyclase activity in the presence of Mg2+ ( 5.0-50 mM ), while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases