Arcuri et al., J Biol Chem 2005
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Expression of S100B in PC12 cells resulted in activation of Akt ; increased levels of p21WAF1, an inhibitor of cyclin dependent kinase (cdk) 2 and a positive regulator of cdk4 ; increased p21WAF1-cyclin D1 complex formation ; and increased phosphorylation of the retinoblastoma suppressor protein, Rb
Tubaro et al., Biochim Biophys Acta 2011
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Moreover, S100B reduces myoblast apoptosis in an MEK-ERK1/2, Akt , JNK, and NF-?B dependent manner