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MET — PLD4
Text-mined interactions from Literome
Bae et al., J Leukoc Biol 1999
:
Trp-Lys-Tyr-Met-Val-D-Met ( WKYMVm ), a peptide that stimulates phosphoinositide ( PI ) hydrolysis in human leukocytes, including monocytes, binds to a unique cell surface receptor and
stimulates superoxide generation, killing of Staphylococcus aureus, and activation of
phospholipase D ( PLD ) in human monocytes
Lee et al., Exp Mol Med 2004
(Calcium Signaling...) :
Trp-Lys-Tyr-Met-Val-Met-NH ( 2 ) ( WKYMVM )
stimulates the activation of
phospholipase D ( PLD ) via Ca ( 2+ ) increase and protein kinase C activation in mouse DC cell line, DC2.4
Kanaho et al., FEBS Lett 1991
:
Stimulation by
N-formyl-Met-Leu-Phe ( fMLP ) of rabbit peritoneal neutrophils, in which phosphatidylcholine was preferentially labeled with 1-O- [ 3H ] octadecyl lyso platelet activating factor,
activated phospholipase D , resulting in the formation of [ 3H ] PA from [ 3H ] PC
Mullmann et al., J Biol Chem 1991
:
Upon
stimulation of these labeled cells with
formyl-Met-Leu-Phe , C5a, or phorbol 12-myristate 13-acetate,
phospholipase D is activated to produce 1-O- [ 3H ] alkylphosphatidic acid ( [ 3H ] alkyl-PA ) and [ 3H ] choline
Kanaho et al., J Biol Chem 1993
:
Of the compounds tested, only DPG interfered with
PLD activation by
N-formyl-Met-Leu-Phe ( fMLP ) in a dose- and time dependent manner