◀ Back to HSP90AA1
HDAC6 — HSP90AA1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
HDAC6 (HDAC6)
→
Hsp90 (HSP90AA1)
(modification, collaborate)
Kovacs et al., Mol Cell 2005*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
HDAC6 (HDAC6)
→
Hsp90/HDAC6 complex (HSP90AA1-HDAC6)
(modification, collaborate)
Kovacs et al., Mol Cell 2005*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
Hsp90 (HSP90AA1)
→
Hsp90/HDAC6 complex (HSP90AA1-HDAC6)
(modification, collaborate)
Kovacs et al., Mol Cell 2005*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
GR (NR3C1)
→
Glucocorticoid receptor/Hsp90/HDAC6 complex (NR3C1-HSP90AA1-HDAC6)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
GR (NR3C1)
→
Hsp90/HDAC6 complex (HSP90AA1-HDAC6)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
Glucocorticoid receptor/Hsp90/HDAC6 complex (NR3C1-HSP90AA1-HDAC6)
→
Hsp90/HDAC6 complex (HSP90AA1-HDAC6)
(modification, collaborate)
-
Reactome Reaction:
HDAC6
→
HSP90AA1
(reaction)
Boyault et al., Genes Dev 2007
-
Reactome Reaction:
HDAC6
→
HSP90AA1
(indirect_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HDAC6
—
HSP90AA1
(physical association, affinity chromatography technology)
New et al., Cell Death Differ 2013
-
IRef Biogrid Interaction:
HDAC6
—
HSP90AA1
(physical association, affinity chromatography technology)
Rao et al., Mol Cancer Ther 2012*
-
IRef Biogrid Interaction:
HDAC6
—
HSP90AA1
(physical association, affinity chromatography technology)
Kekatpure et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
HDAC6
—
HSP90AA1
(physical association, affinity chromatography technology)
Rao et al., Blood 2008*
-
IRef Biogrid Interaction:
HDAC6
—
HSP90AA1
(physical association, affinity chromatography technology)
Bali et al., J Biol Chem 2005*
-
IRef Biogrid Interaction:
HDAC6
—
HSP90AA1
(physical association, affinity chromatography technology)
Kovacs et al., Mol Cell 2005*
Text-mined interactions from Literome
Takakura et al., Nucleic Acids Res 2001
:
Telomerase activation by
histone deacetylase inhibitor in normal cells
Bali et al., J Biol Chem 2005
(Leukemia) :
Depletion of
HDAC6 levels also inhibited the binding of HSP90 to ATP,
reduced the chaperone association of
HSP90 with its client proteins, e.g. Bcr-Abl, and induced polyubiquitylation and partial depletion of Bcr-Abl
Regan et al., Int J Oncol 2011
(Neuroblastoma) :
In addition,
Hsp90 inhibition
reduced HDAC6 expression and enhanced tubulin acetylation
Li et al., Cell Death Differ 2011
:
The underlying mechanism is SAHA 's inhibition of
HDAC6 , an essential positive
regulator of
HSP90
Espallergues et al., J Neurosci 2012
(Disease Models, Animal) :
We provide pharmacological and genetic evidence indicating that the cytoplasmic lysine deacetylase
HDAC6 controls Hsp90 acetylation in the brain, and thereby
modulates Hsp90-GR protein-protein interactions, as well as hormone- and stress induced GR translocation, with a critical impact on GR downstream signaling and behavior