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CASP6 — JAK2

Text-mined interactions from Literome

Rojas et al., Cell Immunol 2002 : Inhibitors of PTK ( AG-126 ), or JAK2 ( AG-490 ) inhibited TNF-alpha and NO production, caspase 1 activation and apoptosis, suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation
Russo et al., Endocrinology 2004 (Neuroblastoma) : Leptin 's antiapoptotic activity required Janus kinase/STAT , MAPK, and phosphatidylinositol-3-kinase activation because the antiapoptotic effects of leptin were abolished, and caspase-3 immunoreactivity increased in the presence of the specific blockers AG490, U0126, or LY294002
Saile et al., Eur J Cell Biol 2004 : Interferon-alpha ( IFN-alpha ) has recently been shown to elicit an antiapoptotic effect on activated HSC by a JAK-2 dependent inhibition of caspase-8 activation
Li et al., Mol Cell Biochem 2007 : Nitric oxide upregulation of caspase-8 mRNA expression in lung endothelial cells : role of JAK2/STAT-1 signaling
Hussner et al., Mol Pharmacol 2012 (Neoplasms) : Furthermore, inhibition of JAK-STAT signaling significantly reduced doxorubicin induced caspase 3 activation and desensitized HeLa cells to doxorubicin cytotoxicity