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PPP2R1A — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Okamoto et al., Mol Cell 2002
:
Thus, our data suggest that cyclin G recruits
PP2A in order to modulate the phosphorylation of Mdm2 and thereby to
regulate both Mdm2 and
p53
Messner et al., J Cell Biochem 2006
:
Inhibition of
PP2A , but not PP5,
mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells
Naoe et al., Cancer Sci 2006
(Hematologic Neoplasms...) :
Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking,
centrosome duplication and
regulation of
p53
Bergstralh et al., Exp Cell Res 2007
(Lung Neoplasms) :
Mass spectroscopy identified the protein as nucleophosmin/B23 (NPM), a multifunctional protein with diverse roles : ribosome biosynthesis,
p53 regulation , nuclear-cytoplasmic shuttling, and
centrosome duplication
Gwinn et al., Mol Cell 2013
:
In this issue of Molecular Cell, Reid et al. ( 2013 ) show that glutamine withdrawal causes
PP2A mediated activation of
p53 through its regulator EDD, linking levels of a critical metabolite to an important regulator of cell survival and proliferation
Mantel et al., Blood 1999
(Polyploidy) :
p53 has already been implicated in
centrosome regulation