Gene interactions and pathways from curated databases and text-mining

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IL17A — IL17D

Text-mined interactions from Literome

Yoshimura et al., J Immunol 2006 : IL-27 also suppressed IL-17 production by activated CD4+ T cells, thereby counteracting IL-23, another IL-12 related cytokine with proinflammatory effects
Sheibanie et al., J Immunol 2007 (Colitis...) : We assessed the effects of PGE ( 2 ) on IL-12, IL-27, and IL-23 and found that PGE ( 2 ) promotes IL-23, inhibits IL-12 and IL-27 expression and release from stimulated DCs, and subsequently induces IL-17 production in activated T cells
Fitzgerald et al., J Immunol 2007 (Encephalomyelitis, Autoimmune, Experimental...) : IL-27 significantly inhibited both nonpolarized and IL-23-driven IL-17 production by myelin-reactive T cells thereby suppressing their encephalitogenicity in adoptive transfer EAE
Anderson et al., J Immunol 2009 (Leishmaniasis, Cutaneous) : IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection
Liu et al., J Interferon Cytokine Res 2011 : The IL-27 mediated inhibition of IL-17 is independent of IL-10 ... Moreover, we also show that IL-27 inhibits IL-17 production by committed Th17 memory cells, which is independent of IL-10
Shen et al., Scand J Rheumatol 2013 (Behcet Syndrome...) : To measure the levels of interleukin (IL)-27, interferon ( IFN ) -?, and IL-17 in serum and supernatants of stimulated peripheral blood mononuclear cells ( PBMCs ) of patients with Behçet 's disease ( BD ) compared with healthy subjects, and to evaluate the effect of recombinant human IL-27 ( rhIL-27 ) on IFN-? and IL-17 production by PBMCs
Fitzgerald et al., J Immunol 2013 (Encephalomyelitis, Autoimmune, Experimental) : IFN-ß-driven IL-27 is responsible for the upregulation of IL-10, but not IL-17 suppression, by IFN-ß in human PBMCs. Surprisingly, IL-10 is not required for the suppression of IL-17 by either IL-27 or IFN-ß in this model or in de novo differentiating Th17 cells, nor is IL-27 signaling required for the suppression of experimental autoimmune encephalomyelitis ( EAE ) by IFN-ß in vivo