Gene interactions and pathways from curated databases and text-mining

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HDAC4 — IL5

Text-mined interactions from Literome

Jee et al., J Biol Chem 2005 (Inflammation) : Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment
Han et al., Biochem J 2006 : We provide evidence that HDAC4 ( histone deacetylase 4 ) and p300, a known HAT ( histone acetyltransferase ), reversibly controlled the activity of the IL-5 promoter in vivo and in vitro, with a concurrent alteration of histone H3 acetylation status at the promoter regions
Rehni et al., Naunyn Schmiedebergs Arch Pharmacol 2012 (Opioid-Related Disorders...) : The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al ( Ac-DEVD-CHO ), a selective interleukin-1ß converting enzyme inhibitor , on the development of naloxone induced opioid withdrawal syndrome both in vitro and in vivo and the effect of histone deacetylase inhibition on histone H3 acetylation in brain