Cesaratto et al., J Mol Med (Berl) 2007
:
Activation of APE1/Ref-1 was followed by a concomitant activation of Egr-1 transcription factor and by an upregulation of PTEN tumor suppressor, an Egr-1 target gene, leading to inhibition of cell growth
Illuzzi et al., PloS one 2013
(Endometrial Neoplasms...) :
APE1 also maintains 3'-5 ' exonuclease and 3'-repair activities, and regulates transcription factor DNA binding through its REF-1 function