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AKT2 — YWHAB
Text-mined interactions from Literome
Guan et al., J Biol Chem 2000
:
Furthermore, expression of
Akt inhibits epidermal growth factor induced
B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo
Zhang et al., J Biol Chem 2001
:
These results indicate that
B-Raf kinase activity is negatively
regulated by
Akt and SGK, suggesting that the cross-talk between the B-Raf and other signaling pathways can be mediated by both Akt and SGK
Hong et al., Exp Cell Res 2013
(MAP Kinase Signaling System...) :
Using androgen deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that
AKT mediated
B-Raf regulation is necessary for ERK1/2 activation