Gene interactions and pathways from curated databases and text-mining

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ACE — RELA

Text-mined interactions from Literome

Yoshiyama et al., J Mol Cell Cardiol 2001 (Myocardial Infarction) : ACE inhibitor and ARB inhibited JNKs, NF- kappa B and AP-1 activities
Cominacini et al., Am J Hypertens 2002 : In this study we have compared the effects of two different angiotensin converting enzyme (ACE) inhibitors, one possessing an active sulfhydryl group ( zofenopril ) and one lacking this group ( enalapril ) on the cellular redox state ( monitored by measuring intracellular reactive oxygen species and thiol status ), expression of adhesion molecules, and activation of NF-kappaB in human umbilical vein endothelial cells ( HUVECs )
Sasaki et al., Am J Physiol Regul Integr Comp Physiol 2005 (Dehydration...) : Furthermore, the same ACE inhibitor and AT1-receptor antagonist each increased the resting NF-kappaB activity in the liver and spleen, although they had no effect on the LPS induced splenic expression of NF-kappaB
Watanabe et al., Peptides 2006 : Furthermore, both an angiotensin-converting-enzyme (ACE) inhibitor and an AT1 receptor antagonist enhanced ( rather than reduced ) the NF-kappaB and AP-1 activities in the hippocampus and/or cerebellum of rats given LPS
Miguel-Carrasco et al., Journal of inflammation (London, England) 2010 : To understand the mechanisms involved in the effect of captopril, mRNA expression of ACE , angiotensin II type I receptor (AT1R) and p22phox ( a subunit of NADPH oxidase ), as well as NF-kappaB activation and expression, were measured in the left ventricle of these animals
Klahr et al., Kidney Int Suppl 1997 (Kidney Diseases...) : ACE inhibition, AT-1 and AT-2 receptor blockade each differentially attenuated NF-kappa B isotype activation