UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family complex (GRB2-SOS1-GAB1_GAB2) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: SHP2 (PTPN11) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → Hck (HCK) (modification, collaborate) Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: Hck (HCK) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction