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HSPG2 — PTEN

Text-mined interactions from Literome

Mhashilkar et al., Mol Ther 2003 (Breast Neoplasms...) : Expression of the PI3K pathway members ( p85 PI3K, FAK, ILK-1, Akt, and PLC-gamma ) was downregulated and expression of the PI3K antagonist PTEN was increased
Alvarez-Breckenridge et al., Hum Mol Genet 2007 (Breast Neoplasms) : As phospholipase C (PLC) is both involved in PLD activation and is regulated by PIP2/3 levels, we investigated the role of PTEN on PLC activation
van Haastert et al., J Cell Biol 2007 : This suggest that PI3-kinase mediated chemotaxis is regulated by PLC , probably through controlling PIP ( 2 ) levels and phosphatase and tensin homologue (PTEN) activity, whereas chemotaxis mediated by PLA2 appears to be controlled by intracellular Ca ( 2+ )
Wang et al., J Am Chem Soc 2008 : To explore the specificity of these types of molecules, we have synthesized D-3-deoxydioctanoylphosphatidylinositol ( D-3-deoxy-diC8PI ), D-3,5-dideoxy-diC8PI, and D-3-deoxy-diC8PI-5-phosphate and their enantiomers, characterized their aggregate formation by novel high-resolution field cycling ( 31 ) P NMR, and examined their susceptibility to phospholipase C (PLC) , their effects on the catalytic activities of PI3K and PTEN against diC8PI and diC8PI-3-phosphate substrates, respectively, and their ability to induce the death of U937 human leukemic monocyte lymphoma cells