Tukov et al., Toxicological sciences : an official journal of the Society of Toxicology 2007
(Disease Models, Animal...) :
To determine whether RAN affects LPS induced TNF release at a time near the onset of liver injury, male Sprague-Dawley rats were treated with 2.5 x 10 ( 6 ) endotoxin units ( EU ) /kg LPS or its saline vehicle ( iv ) and 2 h later with either 30 mg/kg RAN or sterile phosphate buffered saline vehicle ( iv )
Deng et al., J Pharmacol Exp Ther 2008
:
Previous studies showed that RAN augmented serum tumor necrosis factor (TNF)-alpha production and hepatic neutrophil activation after LPS treatment and that both TNF-alpha and neutrophils are crucial for the liver pathogenesis ... In summary, RAN enhanced TNF-alpha production after LPS treatment through augmented p38 activation, and this seems to occur through TACE