Liu et al., Science signaling 2012
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Knocking down SAP97 in IgG? B cells or mutating the putative PDZ binding motif in the BCR tail impaired formation of the immunological synapse, initiation of IgG BCR signaling, and downstream activation of the mitogen activated protein kinase p38 Ingham et al., J Biol Chem 1996
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We show that engaging the B cell antigen receptor (BCR) on the RAMOS B cell line caused both Crk-L and Crk II to associate with several tyrosine phosphorylated proteins
Hashimoto et al., J Exp Med 1998
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Similar to cooperation of Ras with PKC activation in ERK response, both PLC-gamma2 dependent signal and GTPase are required for BCR induced JNK and p38 responses