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AREGB — EGFR

Pathways - manually collected, often from reviews:

• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → amphiregulin (AREGB) (modification, collaborate) Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → EGFR/ErbB3/amphiregulin complex (EGFR-ERBB3-AREGB) (modification, collaborate)
  Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: amphiregulin (AREGB) → EGFR/ErbB3/amphiregulin complex (EGFR-ERBB3-AREGB) (modification, collaborate)
  Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB3 (ERBB3) → EGFR/ErbB3/amphiregulin complex (EGFR-ERBB3-AREGB) (modification, collaborate)
  Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → amphiregulin (AREGB) (modification, collaborate) Jones et al., FEBS Lett 1999*, Johnson et al., J Biol Chem 1993*, Riese et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → EGFR/ErbB2/amphiregulin complex (EGFR-ERBB2-AREGB) (modification, collaborate)
  Jones et al., FEBS Lett 1999*, Johnson et al., J Biol Chem 1993*, Riese et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: amphiregulin (AREGB) → EGFR/ErbB2/amphiregulin complex (EGFR-ERBB2-AREGB) (modification, collaborate)
  Jones et al., FEBS Lett 1999*, Johnson et al., J Biol Chem 1993*, Riese et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR/ErbB2/amphiregulin complex (EGFR-ERBB2-AREGB) → ErbB2 (ERBB2) (modification, collaborate) Jones et al., FEBS Lett 1999*, Johnson et al., J Biol Chem 1993*, Riese et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → amphiregulin (AREGB) (modification, collaborate) Baldys et al., Biochemistry 2009*, Shoyab et al., Science 1989*, Johnson et al., J Biol Chem 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → EGFR/EGFR/amphiregulin/amphiregulin complex (EGFR-AREGB) (modification, collaborate)
  Baldys et al., Biochemistry 2009*, Shoyab et al., Science 1989*, Johnson et al., J Biol Chem 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: amphiregulin (AREGB) → EGFR/EGFR/amphiregulin/amphiregulin complex (EGFR-AREGB) (modification, collaborate)
  Baldys et al., Biochemistry 2009*, Shoyab et al., Science 1989*, Johnson et al., J Biol Chem 1993*
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — AREGB, AREG (direct interaction, pull down) Wong et al., J Biol Chem 1999*
• IRef Dip Interaction: EGFR — AREGB, AREG (physical association, affinity chromatography technology) Wong et al., J Biol Chem 1999*
• IRef Dip Interaction: EGFR — AREGB, AREG (physical association, biochemical) Thompson et al., J Biol Chem 1996*
• IRef Hprd Interaction: EGFR — AREGB, AREG (in vivo) Wong et al., J Biol Chem 1999*
• IRef Ophid Interaction: EGFR — AREGB, AREG (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Willmarth et al., J Mammary Gland Biol Neoplasia 2008 (Breast Neoplasms...) : Amphiregulin , an EGF family growth factor, binds and activates the epidermal growth factor receptor ( EGFR or ErbB1 )
Kariagina et al., Horm Cancer 2010 (Mammary Neoplasms, Experimental...) : Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone dependent rat mammary cancers
Johnson et al., J Biol Chem 1993 : Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2
Mograbi et al., Eur Cytokine Netw 1997 : Amphiregulin (AR) and Heparin Binding EGF-like growth factor ( HB-EGF ) bind and activate the EGFR while Heregulin (HRG) acts through the p185erbB-2 and p180erbB-4 tyrosine kinases