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CYP19A1 — EGF

Text-mined interactions from Literome

Richards et al., J Steroid Biochem Mol Biol 2002 (Breast Neoplasms) : The effects of epidermal growth factor (EGF) , transforming growth factor-beta ( TGFbeta ), and tetradecanoyl phorbol acetate ( TPA ) on aromatase and COXs were studied in primary cultures of normal human adipose stromal cells and in cell cultures of normal immortalized human breast epithelial cells MCF-10F, estrogen-responsive human breast cancer cells MCF-7, and estrogen-unresponsive human breast cancer cells MDA-MB-231 ... EGF and TPA in MCF-7 cells significantly increased aromatase activity while TGFbeta did not ... Aromatase enzyme activity in normal adipose stromal cells was significantly increased by EGF , TGFbeta and TPA after 24h of treatment
Ryde et al., Cancer Res 1992 (Breast Neoplasms) : Aromatase activity in MCF7 cells was significantly stimulated by phorbol 12,13-diacetate [ PDA ], dibutyryl cyclic AMP [ ( Bu ) 2cAMP ], transforming growth factor alpha, and epidermal growth factor individually and PDA and ( Bu ) 2cAMP in combination, while it was inhibited by dexamethasone and unaffected by transforming growth factor beta, fibroblast growth factor, platelet derived growth factor, prolactin, and tamoxifen ... Aromatase activity in T47D cells was stimulated by transforming growth factor alpha, epidermal growth factor , platelet derived growth factor, prolactin, dexamethasone, and cortisol individually and PDA and ( Bu ) 2cAMP in combination
Watanabe et al., J Endocrinol 2006 (Adrenal Cortex Neoplasms) : Effect of epidermal growth factor and prostaglandin on the expression of aromatase ( CYP19 ) in human adrenocortical carcinoma cell line NCI-H295R cells ... We investigated the effects of epidermal growth factor (EGF) and prostaglandins ( PG ) on the expression of aromatase ( CYP19 ) in human adrenocortical carcinoma cell line NCI-H295R cells ... EGF significantly increased aromatase activity and CYP19 gene transcript in NCI-H295R cells ... The results of experiments using protein kinase ( PK ) inhibitors suggest that the cAMP-PKA signaling pathway is involved in the up-regulation of aromatase expression by EGF ... These results suggest that PGE ( 2 ) secondarily acts as an autocrine signal in the up-regulation of aromatase expression by EGF in NCI-H295R cells
Emoto et al., Proc Soc Exp Biol Med 1991 : Although basic fibroblast growth factor ( 1-100 ng/ml ), acidic fibroblast growth factor ( 1 ng/ml ), epidermal growth factor ( 1 ng/ml ), platelet derived growth factor ( 1 ng/ml ), tumor necrosis factor ( 1 ng/ml ), and transforming growth factor-beta 1 ( 1 ng/ml ) have no effect on basal aromatase activity in human skin fibroblasts, all of these growth factors inhibited the ability of dibutyryladenosine 3',5'-cyclic monophosphate to stimulate aromatase activity
Bendell et al., Endocrinology 1990 : As shown previously EGF alone had no effect on basal aromatase activity ... EGF however inhibited FSH induced and FSH plus IGF-I induced aromatase activity ... In this paper we show that EGF also inhibited the FSH induced aromatase activity in the presence of TGF beta, which augmented FSH action on this system ... The action of EGF on 3 beta-hydroxysteroid dehydrogenase ( 3 beta-HSD ) was different from the effect of EGF on aromatase ... EGF can inhibit or stimulate growth and differentiated functions ( aromatase and 3 beta-HSD ), the response depending on the context of the signals that the cell receives from its endocrine and microenvironment
Silva et al., Res Vet Sci 2013 : The effects of epidermal growth factor (EGF) on the in vitro development of isolated goat secondary follicles and the relative mRNA expression of EGF, EGF-R, FSH-R and P450 aromatase in cultured follicles
Mendelson et al., Endocrinology 1986 : Epidermal growth factor (EGF) , fibroblast growth factor ( FGF ), and platelet derived growth factor ( PDGF ) were all without effect on aromatase activity when added by themselves, but markedly inhibited aromatase activity stimulated by ( Bu ) 2cAMP
Tseng et al., Endocrinology 1987 : On the other hand, human CG, epidermal growth factor , human PRL, and insulin did not increase the aromatase activity in the presence or absence of MPA and E2 studied in a limited number of specimens
Evans et al., J Biol Chem 1987 : Effects of dibutyryl cyclic AMP, epidermal growth factor , and phorbol esters on the synthesis of aromatase cytochrome P-450
Dorrington et al., Steroids 1987 : This study describes the effects of insulin, insulin-like growth factor 1 (IGF1), and epidermal growth factor (EGF) on the aromatase activity of granulosa cells isolated from immature rat ovaries ... EGF inhibited the actions of both FSH and insulin on aromatase activity
Steinkampf et al., Mol Cell Endocrinol 1988 : Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells
James et al., Steroids 1987 (Breast Neoplasms) : Studies in which we have examined the effect of epidermal growth factor on aromatase activity in cultured breast adipose tissue suggests that the response may be influenced by a subject 's menopausal status
Schteingart et al., J Steroid Biochem Mol Biol 1995 : Regulation of Sertoli cell aromatase activity by cell density and prolonged stimulation with FSH, EGF , insulin and IGF-I at different moments of pubertal development
McAllister et al., J Clin Endocrinol Metab 1994 : In granulosa-lutein cells, forskolin stimulated aromatase activity was suppressed by EGF , FGF, and TPA
Hurst et al., J Endocrinol Invest 1993 : EGF may mediate luteinized granulosa cell aromatase activity in vivo, and may be a factor responsible for the relative decline in estrogen production in the preovulatory follicle
Hynes et al., J Reprod Fertil 1996 : FSH and IGF-I, but not EGF , stimulated ( P < 0.01 ) aromatase activity of granulosa cells