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EPHB2 — SIRT1

Text-mined interactions from Literome

Li et al., Cell Metab 2008 : SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
Zhao et al., Exp Neurol 2012 (Brain Injuries...) : Furthermore, inhibiting SIRT1 by pharmacological inhibitor salermide or SIRT1 siRNA significantly promotes apoptotic neuron death and reduces ERK1/2 activation induced by mechanical injury in vitro and in vivo ... Inhibition of ERK1/2 activation with PD98059 or U0126 ( two mitogen activated protein kinase kinase inhibitors ) in vitro and in vivo significantly attenuates the SIRT1 and cleaved Caspase-3 expression to protect neuron against TBI induced apoptosis
Shin et al., Neurochem Res 2012 (Brain Ischemia) : Resveratrol increased expression of SIRT1 and phosphorylation of Akt and p38 but inhibited the increase in phosphorylation of ERK1/2