Gene interactions and pathways from curated databases and text-mining

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REN — SPP1

Text-mined interactions from Literome

Ricardo et al., American journal of physiology. Renal physiology 2000 (Hydronephrosis...) : Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor ( AT(1) ) mRNA translation in rat proximal tubules ( PT ) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch
Li et al., Kidney Int 2003 (Diabetes Mellitus, Type 2...) : Osteopontin (OPN) mediates progressive renal injury in various renal diseases by attracting macrophages, and its expression is regulated by the renin-angiotensin system (RAS)
Wang et al., Exp Eye Res 2012 (Disease Models, Animal...) : Effect of SPP 635, a renin inhibitor , on intraocular pressure in glaucomatous monkey eyes ... The effect of topical application of SPP 635, a renin inhibitor , on intraocular pressure ( IOP ) was evaluated in the eyes of monkeys with laser induced unilateral glaucoma ... Topically applied SPP 635, a new renin inhibitor , reduces IOP in glaucomatous monkeys in a dose dependent manner