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TSC1 — WNT3
Text-mined interactions from Literome
Mak et al., Am J Pathol 2005
(Angiomyolipoma...) :
Further, the interaction between
TSC1/TSC2 and components of the beta-catenin degradation complex was
dependent on
Wnt stimulation such that binding of tuberin to GSK3 and Axin was reduced in the presence of Wnt whereas the tuberin Dishevelled interaction was increased
Vigneron et al., Cardiovasc Res 2011
(Disease Models, Animal...) :
A downstream target might be mammalian target of rapamycin (mTOR) since
Wnt can
impair tuberous sclerosis complex-2 (TSC2) phosphorylation by inhibiting GSK-3ß