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INS — PPARG

Text-mined interactions from Literome

Rieusset et al., Diabetes 1999 : This study demonstrates 1 ) that PPAR-gamma mRNA expression is not altered in subcutaneous adipose tissue ( n = 44 ) or in skeletal muscle ( n = 19 ) of subjects spanning a wide range of BMIs ( 20-53 kg/m2 ) and 2 ) that insulin acutely increases PPAR-gamma mRNA expression in human adipocytes both in vivo and in vitro ... Insulin significantly increased PPAR-gamma mRNA levels in lean subjects ( 88 +/- 17 %, n = 6 ), in type 2 diabetic patients ( 100 +/- 19 %, n = 6 ), and in nondiabetic obese patients ( 91 +/- 20 %, n = 6 )
Hamm et al., J Biol Chem 2001 : Furthermore, ectopic expression of a dominant negative isoform of C/EBPbeta ( liver enriched transcriptional inhibitory protein ( LIP ) ) inhibits the induction of C/EBPalpha, PPARgamma2 , and adipose protein 2/fatty acid binding protein by DEX, MIX, and insulin in 3T3-L1 cells without affecting the induction of PPARgamma1 by DEX
Yamamoto et al., Hypertens Res 2002 (Hypertension...) : We investigated the relationship between peroxisome proliferator activated receptor gamma ( PPARgamma ) Pro12Ala substitution and insulin resistance in subjects with normal insulin secretory capacity, since it has been reported that PPARgamma may affect not only insulin resistance but also insulin secretion
Park et al., Diabetologia 2003 : PPARgamma , a member of the nuclear hormone receptor family of transcription factors, plays a key role in adipocyte differentiation and insulin sensitivity
Nakamichi et al., Biochem Biophys Res Commun 2003 : In the present study, we investigated the synergistic effect of PPAR-gamma and its agonist, pioglitazone, on proinsulin biosynthesis and insulin release in a glucose-responsible insulinoma cell line, MIN6 cells
Lupi et al., Am J Physiol Endocrinol Metab 2004 : In conclusion, this study shows that PPARgamma mRNA is expressed in human pancreatic islets, with predominance of PPARgamma ( 2 ) ; exposure to FFA downregulates PPARgamma ( 2 ) and insulin mRNA expression and inhibits glucose stimulated insulin secretion ; exposure to PPARgamma agonists can prevent these effects
Shimomura et al., J Pharmacol Exp Ther 2004 : Our data suggest that PPAR-alpha and -gamma ligands interact directly with the beta-cell membrane and stimulate insulin secretion
Al-Rasheed et al., J Biol Chem 2004 : The present study investigated the effects of insulin and C-peptide on PPARgamma transcriptional activity in opossum kidney proximal tubular cells ... Both insulin and C-peptide induced a concentration dependent stimulation of PPARgamma transcriptional activity ... Neither insulin nor C-peptide had any effect on the expression levels of PPARgamma ... We concluded that insulin and C-peptide can stimulate PPARgamma activity in a ligand independent fashion and that this effect is mediated by PI 3-kinase
Ito et al., Biochem Biophys Res Commun 2004 : PPAR-gamma overexpression significantly suppressed insulin secretion induced by stimulatory concentration of glucose ( p < 0.05 )
Matsui et al., Diabetes 2004 (Glucose Intolerance) : Our results demonstrate that PPAR-gamma protects islets from lipotoxicity by regulating TG partitioning among tissues and that a PPAR-gamma agonist can restore impaired insulin secretion under conditions of islet fat accumulation
Terauchi et al., Nihon rinsho. Japanese journal of clinical medicine 2005 (Diabetes Mellitus...) : While PPARalpha potentiates fatty acid catabolism in the liver and is the molecular target of the lipid lowering fibrates, PPARgamma is essential for adipocyte differentiation and hypertrophy, and mediates the activity of the insulin sensitizing thiazolidinediones
Ravnskjaer et al., Endocrinology 2005 (Insulinoma...) : Peroxisome proliferator activated receptor alpha ( PPARalpha ) potentiates, whereas PPARgamma attenuates , glucose stimulated insulin secretion in pancreatic beta-cells
Westerbacka et al., Diabetologia 2006 (Body Weight...) : Insulin significantly increased expression of ` insulin-sensitivity genes ' SLC2A4, PPARG , PPARGC1A and ADIPOQ in the insulin-sensitive group, while only expression of PPARG and PPARGC1A was increased in the insulin-resistant group
Edvardsson et al., Biochem Biophys Res Commun 2006 : PPARgamma2 , but not PPARgamma1, was up-regulated by insulin and to a lesser extent by oleic acid ... Insulin increased transcription of the PPARgamma2 gene via phosphatidylinositol 3-kinase activation ... The PPARgamma agonist, rosiglitazone, increased PPARgamma2 expression, but not PPARgamma1 , only in the presence of insulin ... In summary, PPARgamma2 is increased in hepatocytes by oleic acid and insulin
Xu et al., Acta Biochim Biophys Sin (Shanghai) 2006 (Insulinoma) : We found that : ( 1 ) endogenous PPARg was activated in a ligand dependent manner in INS-1 cells ; ( 2 ) overexpression of PPARgamma in the absence of PPARgamma ligands enhanced glucose induced insulin secretion, which indicates that the increased glucose induced insulin secretion is a PPARgamma mediated event ; ( 3 ) the addition of both PPARgamma and retinoid X receptor ( RXR ) ligands showed a synergistic effect on the augmentation of reporter activity, suggesting that the hetero-dimerization of PPARgamma and RXR is required for the regulation of the target genes ; ( 4 ) PPARs upregulated both the glucose transporter 2 (GLUT2) and Cb1 associated protein (CAP) genes in INS-1 cells ... Our findings suggest an important mechanistic pathway in which PPARgamma enhances glucose induced insulin secretion by activating the expression of GLUT2 and CAP genes in a ligand dependent manner
Yamanouchi et al., Exp Cell Res 2006 : In ADM, the presence of insulin , which negates an inhibitory effect of Pref-1 on adipogenic differentiation, was required for PPARgamma2 expression in cells from untreated muscle, but not for cells from BPVC treated muscle
Yoshiga et al., Mol Endocrinol 2007 : SH2-B overexpression enhanced mRNA level of PPARgamma in 3T3-L1 cells, whereas PPARgamma levels were reduced in SH2-B-deficient MEFs in response to insulin
Seto-Young et al., J Clin Endocrinol Metab 2007 : Insulin alone stimulated expression of PPAR-gamma , alpha-subunit and beta-subunit of insulin receptor, and IRS-1 up to 174 % ( P < 0.001 ), 692 % ( P < 0.014 ), 275 % ( P < 0.024 ), and 431 % ( P < 0.01 ), respectively ... Insulin and TZDs independently stimulate expression of PPAR-gamma , insulin receptor, IRS-1, and StAR protein in human ovarian cells
Pandey et al., J Cardiovasc Pharmacol 2007 (Hypertension) : These data suggest that PPAR-gamma inhibition results in decreased insulin signaling, particularly in SHR, in an IR-beta phosphorylation dependent manner
Sena et al., Endocrinology 2007 (Cardiomegaly) : Given the important role of insulin signaling in the regulation of myocardial size, we tested the hypothesis that augmentation of myocardial insulin signaling may play a role in PPAR-gamma ligand induced cardiac hypertrophy
Costa et al., Endocr Relat Cancer 2008 (Breast Neoplasms...) : Herein, we studied the effects of PPARgamma and the PPARgamma agonists thiazolidinediones ( TZDs ) on the insulin receptor (IR) , a cell membrane tyrosine kinase receptor protein, whose role is of paramount importance in mediating the metabolic and growth promoting effects of the peptide hormone insulin
Sonoda et al., Endocrinology 2008 : Adiponectin and leptin, and adipocyte-specific genes of adiponectin, leptin, and PPAR-gamma were detected in culture assembly, whereas the lipogenesis factor insulin ( 20 mU/ml ) and inflammation related agent TNF-alpha ( 2 nm ) increased and decreased, respectively, all of their displays
Kummer et al., PPAR research 2008 : Stimulation of PPARgamma receptors by synthetic agonist ( thiazolidinediones ) inducing anti-inflammatory, anti-amyloidogenic, and insulin sensitising effects may account for the observed effects
Zhang et al., Sheng Wu Gong Cheng Xue Bao 2008 (Insulin Resistance) : [ Regulation of SOCS-3, OB, GLUT4 and PPARgamma gene expression by insulin and dexamethasone in porcine primary adipocyte ] ... The simi-quantitative PCR results suggested that insulin increased GLUT4, PPARgamma and SOCS-3 gene expression in primary culture porcine adipocytes and no change of OB gene expression
Uto-Kondo et al., J Nutr 2009 : TRF suppressed the insulin induced mRNA expression of adipocyte-specific genes such as PPARgamma , adipocyte fatty acid binding protein ( aP2 ), and CCAAT/enhancer binding protein-alpha ( C/EBPalpha ) compared with the differentiation of 3T3-L1 preadipocytes into adipocytes only in the presence of insulin ... Alpha-tocotrienol and gamma-tocotrienol decreased the insulin induced PPARgamma mRNA expression by 55 and 90 %, respectively, compared with insulin, whereas alpha-tocopherol increased the mRNA expression ... In addition, gamma-tocotrienol suppressed the insulin induced aP2 and C/EBPalpha mRNA expression, triglyceride accumulation, and PPARgamma protein levels compared with insulin
Fan et al., J Biol Chem 2009 (Insulin Resistance) : Thus the innate FoxO1 transrepression function enables insulin to augment PPARgamma activity, which in turn leads to insulin sensitization, and this feed-forward cycle represents positive reinforcing connections between insulin and PPARgamma signaling
König et al., Eur J Pharmacol 2009 (Carcinoma, Hepatocellular...) : Recently, it was shown that insulin induced gene (Insig)-1 , the key regulator of SREBP activity, is up-regulated by both activation of PPARalpha and PPARgamma
Schinner et al., Br J Pharmacol 2009 : Rosiglitazone caused a PPARgamma dependent inhibition of insulin gene transcription in a beta-cell line
Bumrungpert et al., J Nutr 2009 (Inflammation...) : In addition, gamma-MG prevented the suppression by LPS of insulin stimulated glucose uptake and PPAR-gamma and adiponectin gene expression
Ikeda et al., IUBMB Life 2009 : Insulin and angiotensin II ( AII ), but not high glucose, reduced PPARgamma , aP2 and adiponectin mRNA levels
Du et al., Pharmazie 2009 : Moreover, pre-treatment with testosterone attenuated the insulin induced up-regulation of PPARgamma activity
Wang et al., Chin Med J (Engl) 2009 (Diabetes Mellitus, Type 2...) : And we also observed that ABCC8 as well as the interaction between PPARG and HNF4A may contribute to post-challenge insulin secretion
Kim et al., Biochem Biophys Res Commun 2010 : Transcriptional activity of PPAR-gamma was markedly enhanced by 3-isobutyl-1-methylxanthine ( IBMX ), but not insulin and dexamethasone
Vidal-Puig et al., J Clin Invest 1997 (Obesity, Morbid...) : ( b ) RNA derived from adipose tissue of obese humans has increased expression of PPAR gamma 2 mRNA, as well as an increased ratio of PPAR gamma2/gamma1 splice variants that is proportional to the BMI ; ( c ) a low calorie diet specifically down-regulates the expression of PPAR gamma2 mRNA in adipose tissue of obese humans ; ( d ) insulin and corticosteroids synergistically induce PPAR gamma mRNA after in vitro exposure to isolated human adipocytes ; and ( e ) the in vivo modulation of PPAR gamma2 mRNA levels is an additional level of regulation for the control of adipocyte development and function, and could provide a molecular mechanism for alterations in adipocyte number and function in obesity
Park et al., Diabetes 1997 (Diabetes Mellitus, Type 2...) : To determine whether this receptor is expressed and possibly involved in insulin action/resistance in skeletal muscle, PPAR-gamma mRNA abundance and its regulation by insulin were quantified in muscle tissue and cultures from lean and obese nondiabetic and type II diabetic subjects using competitive reverse transcription-polymerase chain reaction ( RT-PCR ) ... Insulin stimulation of muscle tissue ( by hyperinsulinemic-euglycemic clamp for 3-4 h ) or muscle cultures ( 30 nmol/l for 120 min ) stimulated PPAR-gamma mRNA expression up to fourfold ( 10.0 +/- 2.7 to 41.3 +/- 7.4 x 10 ( 3 ) copies/microg total RNA, P < 0.05, and 174.9 +/- 56.9 to 268.2 +/- 78.6 x 10 ( 3 ) copies/microg total RNA, P < 0.05, respectively ) ... In summary, PPAR-gamma mRNA expression in human skeletal muscle is acutely regulated by insulin and is increased in both obese nondiabetic and type II diabetic subjects in direct relation to BMI and fasting insulinemia
Kruszynska et al., J Clin Invest 1998 (Diabetes Mellitus, Type 2...) : We used a sensitive ribonuclease protection assay, that permits simultaneous measurement of the two isoforms, to examine the effects of obesity and NIDDM, and the effects of insulin , on skeletal muscle levels of PPARgamma1 and PPARgamma2 mRNA
Deeb et al., Nat Genet 1998 (Diabetes Mellitus, Type 2...) : Insulin stimulates the ligand independent activation of PPARgamma1 and gamma2 ( ref. 5 ), however, obesity and nutritional factors only influence the expression of PPARgamma2 in human adipocytes