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INS — PRKAR1B

Text-mined interactions from Literome

Singh et al., J Investig Med 2000 : GlcN inhibits insulin action on both PKA and CK-1 activities
Ortmeyer et al., J Nutr 2001 (Diabetes Mellitus, Type 2...) : The insulin effect ( insulin stimulated minus basal ) on the G6P Ka of GS was strongly positively related to the insulin effect on G6P content ( r = 0.80, P : < 0.0001 ) across the entire group of monkeys
Shen et al., Diabetes Res Clin Pract 2001 : On the other hand, it did not affect PKA stimulated insulin release under either conditions, but in the case of 100 microM, glucose augmented the insulin secretion in the presence of glyceraldehyde and db-cAMP concentration-dependently
Shashkin et al., J Basic Clin Physiol Pharmacol 2001 (Insulin Resistance) : In turn, insulin stimulated cPIP synthase activity was inversely related to both the insulin stimulated fractional activity of PKA ( r=0.89, p < 0.02 ) and the insulin stimulated total PKA activity : r=0.94, p < 0.005
Nesher et al., Diabetes 2002 (Diabetes Mellitus, Type 2) : In the isolated rat pancreas, accelerated calcium entry or activation of protein kinase (PK)-A or PKC result in no insulin response in the absence of fuel metabolism
Lee et al., Experimental biology and medicine (Maywood, N.J.) 2003 : Leptin has been reported to activate phosphatidylinositol 3-kinase (PI 3-K) and subsequently phosphodiesterase ( PDE ) to impair protein kinase A (PKA) induced insulin secretion from cultured islets of neonatal rats ... We determined if PKA induced insulin secretion was also hyperresponsive in islets from Lep ( ob ) /Lep ( ob ) mice, and if leptin impaired this pathway in islets from these mice
Liu et al., Pancreas 2004 : However, insulin secretion mediated by PKA and PKC activation was desensitized in vanadate treated cells
Wan et al., J Gen Physiol 2004 (Calcium Signaling) : We propose that PKA and PKC promote insulin secretion by increasing the number of vesicles that are highly sensitive to Ca ( 2+ )
Méndez et al., Mol Cell Endocrinol 2005 : Furthermore, insulin and IGF-I blocked the activation of PKA induced by sLH and these effects were correlated with changes in the total protein content of the catalytic ( C ) and type II regulatory ( RII ) subunits of PKA
Sengenes et al., Med Sci (Paris) 2005 : Human fat cell lipolysis was considered until recently to be an exclusive cAMP/protein-kinase A (PKA) regulated metabolic pathway under the control of catecholamines and insulin
Thams et al., Eur J Endocrinol 2005 : In islets cultured at 5.5 mmol/l glucose, and then perifused in physiological Krebs-Ringer medium, the PKA inhibitors, H89 ( 10 micromol/l ) and PKI 6-22 amide ( 30 micromol/l ) did not inhibit glucose ( 16.7 mmol/l ) -induced insulin secretion, but inhibited stimulation by the adenylyl cyclase activator, forskolin ( 10 micromol/l )
Shimono et al., Diabetes Res Clin Pract 2005 : Neither GTP nor activated PKA in the absence of PKC activation increased insulin release under Ca2+ depleted condition in the presence of ATP, but both enhanced insulin secretion in the presence of ATP when PKC was activated
Sengenes et al., Med Sci (Paris) 2005 : Human fat cell lipolysis was considered until recently to be an exclusive cAMP/protein-kinase A (PKA) regulated metabolic pathway under the control of catecholamines and insulin
Choi et al., Mol Cell Biol 2010 (Insulin Resistance) : Furthermore, insulin regulates total PKA activity in an Akt dependent manner
Bonfleur et al., Metabolism 2011 : Insulin secretion induced by the protein kinase A (PKA) activators forskolin and 3-isobutyl-1-methyl-xanthine, in the presence of 11.1 mmol/L glucose, was lower in LDLR ( -/- ) islets and was normalized in the presence of the protein kinase C pathway activators carbachol and phorbol 12-myristate 13-acetate
Persaud et al., Biochem Biophys Res Commun 1990 : The involvement of cyclic AMP dependent protein kinase A (PKA) in the exocytotic release of insulin from rat pancreatic islets was investigated using the Rp isomer of adenosine 3',5'-cyclic phosphorothioate ( Rp-cAMPS ) ... These results suggest that cAMP induced activation of PKA is not essential for either basal or glucose stimulated insulin secretion from rat islets
Benninger et al., J Physiol 2011 : Forced elevation of cAMP led to PKA mediated increases in insulin secretion from islets lacking gap-junctions, but not from islets expressing Cx36 gap junctions
Dezaki et al., Methods Enzymol 2012 : Ghrelin attenuates the glucose induced cAMP production and PKA activation, which drives activation of Kv channels and suppression of the glucose induced [ Ca ( 2+ ) ] ( i ) increase and insulin release in ß-cells
Ying et al., FEBS Lett 2012 (Synaptic Transmission) : Knock-down of syntabulin by shRNA reduced both basal and glucose stimulated insulin secretion, and diminished cAMP-Epac2 and cAMP-PKA potentiated insulin secretion
Kaihara et al., Diabetes 2013 (Hyperglycemia...) : In response to sustained hyperglycemia, PKA activity potentiated both acute and sustained insulin release ... Intracellular calcium signaling was unaffected by PKA activation, suggesting that the effects of PKA on acute-phase insulin secretion are mediated by the phosphorylation of proteins involved in ß-cell exocytosis
Hajnóczky et al., Biochem J 1993 : However, the amount of compartmentalized fura-2 that could be quenched by Mn2+ in the presence of maximal Ins ( 1,4,5 ) P3 was increased by PKA
Enan et al., Reprod Toxicol 1996 : The stimulatory effect of TCDD on postnuclear PKA activity was enhanced by insulin and TCDD reversed the negative effect of FK, but there was no effect of either insulin or FK on the inhibition by TCDD of nuclear PKA activity
Harris et al., Biochem Biophys Res Commun 1997 : We have now modified PKI sequences by N-terminal myristoylation to enhance their membrane permeability, and have used the myristoylated ( myr ) peptides to investigate the role of PKA activation in glucose induced insulin secretion from intact pancreatic beta-cells ... In experiments using intact islets, myr PKI14-22 caused a concentration dependent inhibition of insulin secretion in response to the PKA activators dibutyryl cyclic AMP and forskolin, suggesting that it gained access to the cytosolic compartment of intact beta-cells and inhibited PKA in situ ... However, these concentrations of myr PKI14-22 did not inhibit insulin secretion in response to glucose suggesting that the activation of PKA is not required for the initiation of glucose induced insulin secretion
Ortmeyer et al., J Basic Clin Physiol Pharmacol 1997 (Diabetes Mellitus, Type 2...) : Insulin decreases skeletal muscle cAMP dependent protein kinase (PKA) activity in normal monkeys and increases PKA activity in insulin-resistant rhesus monkeys