◀ Back to INS

INS — RBP4

Text-mined interactions from Literome

Yang et al., Nature 2005 (Diabetes Mellitus, Type 2...) : Increasing serum RBP4 induces hepatic expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase ( PEPCK ) and impairs insulin signalling in muscle
Ost et al., FASEB J 2007 : However, little is known about how RBP4 affects insulin signaling
Camera et al., Minerva Med 2008 (Insulin Resistance...) : RBP-4 can attenuate insulin signalling in skeletal muscle and induce hepatic gluconeogenesis
Lewandowski et al., Gynecol Endocrinol 2008 (Diabetes, Gestational...) : Retinol binding protein-4 (RBP-4) may increase insulin resistance (IR) in animals, with elevated levels reported in humans with obesity and type 2 diabetes
Ou et al., Horm Metab Res 2011 (Disease Models, Animal...) : Retinol binding protein 4 (RBP4) is an adipokine secreted by adipose tissue and liver and contributes to insulin resistance (IR) in animals
Berry et al., Proc Natl Acad Sci U S A 2011 : These observations establish that the parental vitamin A molecule is a transcriptional regulator in its own right, reveal that the scope of biological functions of the vitamin is broader than previously suspected, and provide a rationale for understanding how RBP and retinol regulate energy homeostasis and insulin responses
Norseen et al., Mol Cell Biol 2012 (Insulin Resistance) : Retinol binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol independent mechanism ... Here we show that RBP4 induces expression of proinflammatory cytokines in mouse and human macrophages and thereby indirectly inhibits insulin signaling in cocultured adipocytes
Karakas et al., Gynecol Endocrinol 2013 : We investigated serum FABP4 and RBP4 responses to insulin sensitizing and lipid lowering therapies in polycystic ovary syndrome ( PCOS ) ... Insulin sensitizing and lipid lowering therapies did not affect FABP4 or RBP4 levels in PCOS
Berry et al., J Biol Chem 2013 (Insulin Resistance...) : However, ablation of Stra6 effectively protects mice from RBP induced suppression of insulin signaling
Cheng et al., Biochem Cell Biol 2013 : Moreover, the activation of insulin signaling mediated by knockdown RBP4 in porcine preadipocytes was recovered in the suppression of LY294002