◀ Back to PCNA
MDM2 — PCNA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2001
:
Cyclin a-CDK phosphorylation
regulates MDM2 protein interactions
Okamoto et al., Mol Cell 2002
:
Cyclin G expression also
results in reduced phosphorylation of human
Hdm2 at S166
Zhao et al., Mol Cancer Res 2003
(Osteosarcoma) :
Notably,
cyclin G1 is
down-regulated by
Mdm2 through proteasome mediated degradation
Banks et al., Cell cycle (Georgetown, Tex.) 2006
:
Our data further showed that
MDM2/HDM2 is rapidly proteolyzed in response to UV irradiation and this process is
regulated by CUL4/DDB1 and
PCNA
Frum et al., Mol Cancer Res 2009
:
Silencing of cyclin dependent kinase (cdk) inhibitor p16 prevents
MDM2 mediated inhibition of
cyclin A expression, implicating its role in the process ...
MDM2 mediated repression of
cyclin A expression induces G ( 1 ) -S arrest, which can be rescued by ectopic expression of cyclin A. Cancer cells lacking p53, p16, or BRG1 escape MDM2 mediated repression of cyclin A expression and growth arrest
Groehler et al., J Cell Biol 2010
(Genomic Instability) :
A chromatin bound kinase, ERK8, protects genomic integrity by inhibiting
HDM2 mediated degradation of the DNA clamp
PCNA
Léveillard et al., J Biol Chem 1997
:
The MDM2 C-terminal region binds to TAFII250 and is required for
MDM2 regulation of the
cyclin A promoter ... Expression of
MDM2 activates the
cyclin A gene promoter but not c-fos, showing that the effects of MDM2 are specific ... The C-terminal region of MDM2, which contains the Ring finger, interacts with TAFII250 and is required for
regulation of the
cyclin A promoter by
MDM2