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PCBD1 — TNF

Text-mined interactions from Literome

Lee et al., Science 2000 (Cachexia...) : A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappaB (NF-kappaB) activity and tumor necrosis factor (TNF) mediated programmed cell death (PCD)
Friedman et al., Biol Reprod 2000 : TNF alpha induced programmed cell death (PCD) in dose- and time dependent manners of cultured luteal endothelial cells ( LECs ) but not of in vitro luteinized steroidogenic cells ... Several lines of evidence are provided to show that progesterone regulates luteal cell survival : 1 ) CL and LECs express progesterone receptor mRNA, 2 ) physiological levels of the steroid abolished TNF alpha induced PCD of LECs, and 3 ) progesterone producing cells are protected from PCD ... In conclusion, this study suggests that TNF alpha induced PCD during structural luteolysis is mediated by TNFRI, primarily affects endothelial cells, and that the decline in progesterone, preceding structural luteolysis, is a prerequisite for the initiation of apoptosis in endothelial cells
Mannello et al., Apoptosis 2001 (Neoplasms) : TIMP-3 is the only member which is tightly bound to ECM, inhibits TNF-alpha converting enzyme and induces PCD through the stabilization of TNF-alpha receptors on the cell surface
Lange et al., Biochem Biophys Res Commun 2005 : Here, we demonstrate that stable transfection of a cDNA encompassing the C-terminal apoptosis inhibitory domain ( AID ) of FE65-like protein 1 into mouse L929 fibrosarcoma cells protects from caspase independent as well as from apoptotic PCD induced by TNF
Bubici et al., Histol Histopathol 2006 (MAP Kinase Signaling System) : This latter activity of NF-kappaB antagonizes programmed cell death (PCD) induced by the proinflammatory cytokine tumor necrosis factor (TNF)alpha and plays an important role in immunity, lymphopoiesis, osteogenesis, tumorigenesis and radio- and chemoresistance in cancer ... Notably, NF-kappaB also blunts accumulation of reactive oxygen species ( ROS ), which themselves are pivotal elements for induction of PCD by TNFalpha , and this suppression of ROS formation mediates an additional protective activity recently ascribed to NF-kappaB
Thon et al., FASEB J 2005 : Under conditions where apoptosis is either not initiated or actively inhibited, TNF induces caspase independent PCD in L929 fibrosarcoma cells, NIH3T3 fibroblasts, human leukemic Jurkat T cells, and lung fibroblasts by increasing intracellular ceramide levels prior to the onset of cell death
Papa et al., Cell Death Differ 2006 (Disease...) : Activation of NF-kappaB antagonizes programmed cell death (PCD) induced by tumor necrosis factor-receptors (TNF-Rs) and several other triggers
Thon et al., Exp Cell Res 2006 : Here, we demonstrate for the first time that the single murine receptor for (TNF) related apoptosis inducing ligand ( mTRAIL-R2 ) can induce a caspase independent form of PCD with necrosis-like features in addition to apoptosis ... In concert with the enhanced resistance of AC-overexpressing cells against caspase independent PCD induced by TNF , our results suggest that ceramide acts as a common mediator of caspase independent PCD caused by death receptors such as mTRAIL-R2 and TNF-R55
Pham et al., Mol Cell Biol 2007 (Neoplasms) : Twist-1 is an evolutionarily conserved target of NF-kappaB, blocks PCD induced by chemotherapeutic drugs and TNF-alpha in NF-kappaB-deficient cells, and is essential to counter this PCD in cancer cells
Papa et al., J Biol Chem 2007 : These data provide a basis for Gadd45beta mediated blockade of MKK7, and ultimately, TNFalpha induced PCD
Mauro et al., Methods Mol Biol 2009 (Neoplasms) : NF-kappaB also counters programmed cell death (PCD) induced by the proinflammatory cytokine tumor necrosis factor (TNF)alpha , and this activity of NF-kappaB is crucial for organismal physiology, chronic inflammation, and tumorigenesis
Mangan et al., J Immunol 1991 : IL-1 beta and TNF-alpha prevent monocyte PCD , which suggests that viability may be regulated by biologically active peptides released during inflammation
Malorni et al., FEBS Lett 1993 : The present paper focuses on some specific aspects of PCD induced by the cytokine tumor necrosis factor (TNF)