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ST8SIA2 — TNF

Text-mined interactions from Literome

Zhang et al., Life Sci 2001 : In this study, we investigated whether CV6209, a PAF antagonist, could modulate Shiga toxin (Stx) induced TNF-alpha production in human monocytic cells ... CV6209 significantly suppressed Stx induced TNF-alpha production in a dose- and time dependent manner ... Reverse transcription-polymerase chain reaction ( RT-PCR ) analysis showed that CV6209 suppressed Stx mediated TNF-alpha mRNA expression ... Our results indicated that CV6209 had an important regulatory effect on Stx induced TNF-alpha production and gene expression
Ohara et al., Antimicrob Agents Chemother 2002 (Escherichia coli Infections...) : In Stx injected mice, azithromycin significantly suppressed Stx induced TNF-alpha , IL-1beta, and IL-6 levels in serum and improved the outcome as assessed by survival rate