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EGFR — SLC22A3

Text-mined interactions from Literome

Murillo et al., Oncogene 2005 : Inhibition of EGFR does not block the epithelial-mesenchymal transition (EMT) induced by TGF-beta1 in hepatocytes, which indicates that activation of EGFR plays an essential role in impairing apoptosis, but it is dispensable for the EMT process
Heijink et al., Am J Respir Cell Mol Biol 2010 : We propose that TGF-beta secretion and dysregulated EGFR signaling may increase epithelial vulnerability to allergens and trigger the induction of EMT , a hitherto unrecognized contributor to airway remodeling in asthma
Cowden Dahl et al., Neoplasia (New York, N.Y.) 2009 (Disease Progression...) : Importantly, overexpression of the epidermal growth factor receptor (EGFR) in ovarian cancer correlates with poor disease outcome and induces EMT in ovarian cancer cells
Reischauer et al., PLoS Genet 2009 : Further, we found that epidermal neoplasia and EMT in pen/lgl2 mutant epidermal cells is promoted by ErbB signalling, a pathway of high significance in human carcinomas
Zuo et al., Breast Cancer Res 2010 (Breast Neoplasms...) : To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha, caveolin-1 (Cav-1), and epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed EMT in MB468 cells can be blocked by EGFR inhibitor ( AG1478 ) and PI3K inhibitor ( wortmannin )
Gan et al., Oncogene 2010 (MAP Kinase Signaling System...) : Knockdown of endogenous Snail also prevents EGFR mediated downregulation of E-cadherin, EMT and cell migration
Wendt et al., Oncogene 2010 (Breast Neoplasms...) : Mechanistically, EMT induced by TGF-ß increased cell-surface levels of EGFR and prevented its physical interaction with E-cadherin, leading instead to the formation of oncogenic signaling complexes with TßR-II
Comamala et al., Br J Cancer 2011 (Carcinoma...) : Our findings suggest that CA125/MUC16 plays a role in EMT , presumably through its interaction with E-cadherin and ß-catenin complexes and by modulating EGFR and its downstream signalling pathway in NIH : OVCAR3 cells
Al Moustafa et al., Front Biosci (Schol Ed) 2012 (Carcinoma...) : The purpose of this review is to summarize current information regarding the role of EGF-R signaling on EMT during human cancer progression and metastasis
Maseki et al., Br J Cancer 2012 (Carcinoma...) : These results suggest that EMT in the gefitinib-resistant cells is mediated by the downregulation of EGFR and compensatory activation of Akt/GSK-3ß/snail pathway