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COL2A1 — IGF1
Text-mined interactions from Literome
Boehm et al., Arthritis Rheum 2007
:
Inhibition of Hsp90 with 100 nM or 500 nM geldanamycin blocked
IGF-1 induced cell proliferation, Akt and p42/44 activation, and
COL2A1 expression
Fernandez-Cancio et al., Growth Horm IGF Res 2008
:
IGF-I stimulated IGF-I, IGFBP3, SOX9,
COL2A1 and aggrecan expression whereas it inhibited IGF-IR expression
Zhang et al., Osteoarthritis Cartilage 2009
(MAP Kinase Signaling System) :
IGF-1 increased
Col2a1 mRNA expression in rat endplate chondrocytes in a time- and dose dependent manner ... The PI3K inhibitor Wartmannin significantly inhibited the
IGF-1 effect on
Col2a1 mRNA expression but did not affect IGF-1 induced repression of MMP-13 expression ... In contrast, the ERK/MAPK inhibitor PD98059 significantly inhibited the effect of IGF-1 on MMP-13 mRNA repression and enhanced
IGF-1 induced
Col2a1 mRNA expression
Fernández-Cancio et al., Growth Horm IGF Res 2009
:
IGF-I stimulated IGF-I, IGFBP-3, SOX9,
COL2A1 and aggrecan expression and opposed COL2A1 and aggrecan gene expression inhibition by VitD
Renard et al., J Mol Med (Berl) 2012
:
These data demonstrate the role of Sox9, Sp1/Sp3, and euchromatin associated factors ( p300, Tip60 ) in the
IGF-I induced upregulation of
COL2A1 , indicating possible use of this growth factor in articular cartilage engineering applications to promote repair in patients with degenerative diseases, such as osteoarthritis
Koshimizu et al., J Biol Chem 2012
:
Knockdown of vinculin in the metatarsal organ culture abrogated the IGF-I induced growth and inhibited the
up-regulation of
Col2a1 and aggrecan expression by
IGF-I